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Chapter and Conference Paper
Numerical Simulation of Beach Changes on Seisho Coast by Typhoon Jongdari
The Seisho coastline, in Kanagawa Prefecture, Japan, has historically suffered the consequences of the many typhoons that traverse the area. In 2018, this part of the country was damaged by Typhoon Jongdari, w...
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Article
Open AccessRecombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector
Multiple approaches utilizing viral and DNA vectors have shown promise in the development of an effective vaccine against HIV. In this study, an alternative replication-defective flavivirus vector, RepliVax (R...
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Article
Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation
Class IA phosphatidylinositol 3-kinases (PI3Ks) are composed of p110 catalytic and p85 regulatory subunits. How regulatory subunits modulate PI3K activity remains only partially understood. Here we identified ...
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Article
Renal Artery Aneurysms
A renal artery aneurysm is defined as a dilated segment of renal artery that exceeds twice the diameter of a normal renal artery. Although rare, the diagnosis and incidence of this entity have been steadily in...
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Article
Open AccessSystems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C
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Article
Open AccessAntigen-specific T lymphocyte responses elicited by a DNA – MVA HIV CN54gp140 immunization regime are significantly altered by the TLR4 adjuvant GLA
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Article
Open AccessImmune responses triggered by HIV/AIDS vaccine candidates, derived from MVA-B, with deletions in several immune regulatory genes
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Article
Open AccessComparison of the depth of vaccine-elicited HIV-1 Env epitope-specific CD8+ T lymphocyte responses
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Article
Open AccessRegulation of the tumor suppressor PTEN by SUMO
The crucial function of the PTEN tumor suppressor in multiple cellular processes suggests that its activity must be tightly controlled. Both, membrane association and a variety of post-translational modificati...
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Article
SIRT1 stabilizes PML promoting its sumoylation
SIRT1, the closest mammalian homolog of yeast Sir2, is an NAD+-dependent deacetylase with relevant functions in cancer, aging, and metabolism among other processes. SIRT1 has a diffuse nuclear localization but is...
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Article
Open AccessP17-23. Enhanced expression of HIV antigens and improved antigen presentation after infection with replication competent attenuated vaccinia virus in vitro
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Article
Open AccessP17-07. Insertion of a vaccinia virus host range (hr) gene into NYVAC-B genome potentiates immune responses against HIV-1 antigens
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Article
Open AccessP02-04. Multimeric soluble CD40 ligand efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus strains
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Article
Role of mitochondria in apoptosis induced by the 2‐5A system and mechanisms involved
The 2‐5A system (2-5OAS/RNaseL) is composed of the 2′,5′oligoadenylate synthetase 1 (2-5OAS1) and 2-5A-dependent RNase (RNaseL), enzymes that play a key role in antiviral defence mechanisms. Activation of the ...
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Article
Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration
MVA is a candidate vector for vaccination against pathogens and tumors. Little is known about its behaviour in mucosal tissues. We have investigated the fate and biosafety of MVA, when inoculated by different...
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Article
Visna/maedi virus Env protein expressed by a vaccinia virus recombinant induces cell-to-cell fusion in cells of different origins in the apparent absence of Env cleavage: role of glycosylation and of proteoglycans
The in vivo productive infection by the ovine Visna/maedi lentivirus (VISNA) is restricted to cells of the monocyte/macrophage lineage. The basis for this restriction is not understood. Although the VISNA envelo...
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Article
Growth of moderately halophilic bacteria isolated from sea water using phenol as the sole carbon source
Moderately halophilic bacteria utilizing phenol as the sole carbon source were isolated by selective enrichment from sea water. The isolate (Gram-negative motile rods) was identified asDeleya venusta. It grew wel...
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Article
Recombinant proteins produced by vaccinia virus vectors can be incorporated within the virion (IMV form) into different compartments
Vaccinia virus (VV) is one of the largest and most complex of animal viruses, with a virion that contains about 100 different polypeptides. Assembly of the viral proteins occurs in discrete cytoplasmic sites ...
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Article
Ten years inventorying the Iberian fauna: results and perspectives
The Iberian Peninsula is one of the richest European regions in animal species diversity. Since 1988, the objective of the nationally funded Fauna Ibérica project has been to carry out a well-documented invent...
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Article
The Yeast Genome Directory
This directory was made possible by a unique international collaboration between the 633 scientists whose names appear below. It represents both the first published description of the complete sequence of most...
