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Article
Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration
MVA is a candidate vector for vaccination against pathogens and tumors. Little is known about its behaviour in mucosal tissues. We have investigated the fate and biosafety of MVA, when inoculated by different...
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Article
The role of M cells in mucosal immunity
Mucosa-associated lymphoid tissue in the respiratory and digestive tracts are covered by a specialized epithelium, the follicle-associated epithelium, which includes M cells, which are specialized for the upt...
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Chapter
Antibody-Mediated Protection of Mucosal Surfaces
Mucosal surfaces of the oral cavity, the digestive and urogenital tracts, and the airways are protected against environmental pathogens by innate and adaptive immune defense mechanisms. Innate defense involves...
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Chapter
Dendritic Cells of the Murine Peyer’s Patches Colocalize with Salmonella Typhimurium Avirulent Mutants in the Subepithelial Dome
Salmonella typhimurium is an enteropathogenic bacterium that invades the murine Peyer’s patches (PP), the mucosal lymphoid tissue of the small intestine (1), and later spreads systemically result...
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Chapter
Vaccines for the treatment and prevention of Helicobacter pylori infection
An immunological approach or a vaccine approach to clear chronic Helicobacter pylori infection was initially rejected by many investigators and clinicians, based on the observation that natural immunity was unabl...
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Chapter
Cloning of the Rearranged Variable Regions of Mouse Immunoglobulin Heavy and Light Chain Genes Using the Polymerase Chain Reaction
A novel strategy has been designed for the isolation of rearranged genomic fragments encoding the L-VH-D-JH and L-Vκ/λ-Jκ/λ-Jica regions of mouse immunoglobulin genes. This strategy is based on the PCR amplifi...
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Chapter
The Polymeric Immunoglobulin Receptor: Signals For Polarized Expression
Cells such as epithelial or neuronal cells, when fully differentiated, exhibit a clear functional asymmetry related to morphological asymmetry. Differences in plasma membrane composition are maintained by the ...
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Chapter
Functional expression of the gastric H,K-ATPase in Xenopus oocytes
The gastric parietal cell H,K-ATPase mediates the secretion of acid by an energy dependent, electroneutral exchange of intracellular H+ against extracellular K+. Among the different known P-type ATPases, the α-su...
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Article
Microbiology
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Chapter and Conference Paper
Role of Transepithelial Transport in Triggering a Mucosal Immune Response and in Delivery of Mucosal Antibodies into Secretions
Many pathogens, including viruses, bacteria and parasites as well as toxins and allergens, gain entry into the organism by crossing the epithelia of the digestive, respiratory or genital tracts. Mucosal surfac...
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Article
Attempts to quantitate immunocytochemistry at the electron microscope level
The ability to localize intracellular macromoleculesin situ by high resolution techniques has been made possible by the development of antibody labelling of thin sections obtained either from tissues embedded in ...
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Article
Microfilament-rich cells in the toad bladder epithelium
Basal cells of the bladder epithelium ofBufo marinus have been found heterogenous and consist of microfilament-rich cells (MFR-cell) and undifferentiated cells (Un-cell). The MFR-cell, which represents approximat...
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Article
Isolation and separation of toad bladder epithelial cells
The epithelium of the urinary bladder ofBufo marinus is composed of 5 cell types, i.e., granular (Gr), mitochondria-rich (MR) and goblet (G) cells which face the urinary lumen, microfilament-rich (MFR) and undiff...
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Chapter and Conference Paper
Transfer of Humoral Secretory and Cellular Immunity from Mother to Offspring
Birth represents a drastic change in the environment of young mammals. During gestation the fetus is protected from contact with foreign antigens and microorganisms to which the mother is exposed. At birth whe...
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Article
Résorption intestinale de la ferritine chez deux espèces animales aux possibilités d'absorption protéique néonatale différentes
The intestinal absorption of equine ferritin was studied in newborn rats and rabbits by means of electron microscopy and immunological tests.
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Article
Morphologie comparée de la muqueuse intestinale de deux espèces animales aux possibilités d'absorption protéique néonatale différentes
The morphological features of intestinal epithelium have been studied by light and electron microscopy in two species; in the rat which is able to absorb proteins, such as antibodies and in the rabbit which do...
