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  1. No Access

    Article

    Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

    Class IA phosphatidylinositol 3-kinases (PI3Ks) are composed of p110 catalytic and p85 regulatory subunits. How regulatory subunits modulate PI3K activity remains only partially understood. Here we identified ...

    C F de la Cruz-Herrera, M Baz-Martínez, V Lang, A El Motiam, J Barbazán… in Oncogene (2016)

  2. No Access

    Article

    SUMOylation regulates AKT1 activity

    Serine threonine kinase AKT has a central role in the cell, controlling survival, proliferation, metabolism and angiogenesis. Deregulation of its activity underlies a wide range of pathological situations, inc...

    C F de la Cruz-Herrera, M Campagna, V Lang, J del Carmen González-Santamaría… in Oncogene (2015)

  3. No Access

    Article

    Kaposi’s sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation

    The pocket proteins retinoblastoma protein (pRb), p107 and p130 are the key targets of oncoproteins expressed by DNA tumor viruses. Some of these viral proteins contain an LXCXE motif that mediates the interac...

    L Marcos-Villar, P Gallego, C Muñoz-Fontela, C F de la Cruz-Herrera, M Campagna… in Oncogene (2014)

  4. Article

    Open Access

    Regulation of the tumor suppressor PTEN by SUMO

    The crucial function of the PTEN tumor suppressor in multiple cellular processes suggests that its activity must be tightly controlled. Both, membrane association and a variety of post-translational modificati...

    J González-Santamaría, M Campagna, A Ortega-Molina, L Marcos-Villar… in Cell Death & Disease (2012)

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