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The Construction and Sabotage of Successful Agricultural Lands in Semiarid Lands: A Case Study of Vitivinicultural Areas in Northern México
The land-use planning effort for a semiarid watershed where wine is the staple economic product was evaluated. Over the last 30 years, three top-down local public policies have been in effect with the shared o...
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Article
Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors
We have identified a new t(1;21)(p32;q22) chromosomal translocation in a MDS/AML patient that results in expression of an aberrant C-terminally truncated RUNX1 protein lacking several regulatory domains. As si...
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Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
Cancer-related human chromosomal translocations are generated through the illegitimate joining of two non-homologous chromosomes affected by double-strand breaks (DSB). Effective methodologies to reproduce pre...
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Article
An integration-defective lentivirus-based resource for site-specific targeting of an edited safe-harbour locus in the human genome
Optimized gene transfer into human cells are still challenging the promise of human stem and induced pluripotent stem cells as resources for disease models, diagnostic screens and personalized cell therapy. Th...
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Article
Open AccessHuman mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy
In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical for their clinical use. However, the relationship bet...
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Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver
In utero cell and gene therapies constitute alternative strategies to the postnatal treatment of inherited diseases. Fetal hematopoietic progenitors could be a potential source of donor cells for these strategies...
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Formation of vortices near abrupt nano-channel height changes in electro-osmotic flow of aqueous solutions
We perform computational fluid dynamics simulations of electro-osmotic flow in nano-channels and examine the effects of sudden changes in channel cross-section area (e.g., channels with a backward-facing step)...
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Evaluation of a rayleigh-number-based freckle criterion for Pb-Sn alloys and Ni-base superalloys
A criterion for predicting the formation of freckles for Pb-Sn and Ni-base superalloys is evaluated using available experimental data. The criterion is based on a maximum value of the Rayleigh number, which in...
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Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration
MVA is a candidate vector for vaccination against pathogens and tumors. Little is known about its behaviour in mucosal tissues. We have investigated the fate and biosafety of MVA, when inoculated by different...
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35th Annual Meeting of the European Association for the Study of Diabetes
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The Role of an Interface Misfit Dislocation in Blocking the Glide of a Threading Dislocation in a Strained Epitaxial Layer
The glide of a threading dislocation in a strained layer may be impeded as it encounters interface misfit dislocations on intersecting glide planes. An estimate of the change in driving force on the threading ...
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Article
Mechanics of Elastic Dislocations in Strained Layer Structures
Application of the elastic continuum theory of dislocations to modeling of phenomena associated with elastic strain relaxation in strained layer epitaxial heterostructures is discussed. The concept of critical...
