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Open AccessHOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives
We assessed whether HOMA-IR and the Matsuda Index are associated with transitions through stages of type 1 diabetes.
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Article
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to therapies1. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour microenvironment, leading to dysregulate...
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Article
Open AccessEfficacy and Safety of Reparixin in Patients with Severe COVID-19 Pneumonia: A Phase 3, Randomized, Double-Blind Placebo-Controlled Study
Polymorphonuclear cell influx into the interstitial and bronchoalveolar spaces is a cardinal feature of severe coronavirus disease 2019 (COVID-19), principally mediated by interleukin-8 (IL-8). We sought to de...
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Article
Open AccessFibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth
The pancreatic microenvironment has a defensive role against cancer but it can acquire tumor-promoting properties triggered by multiple mechanisms including alterations in the equilibrium between proteases and...
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Article
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at disease onset. A single AAb, sometimes at low titre, is often detected in some individuals, making t...
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Open AccessDirected self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes
Intrahepatic islet transplantation is the standard cell therapy for β cell replacement. However, the shortage of organ donors and an unsatisfactory engraftment limit its application to a selected patients with...
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Book
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Chapter
Immune Evasive Stem Cell Islets
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-secreting β cells by the immune system (American Diabetes, A., Diabetes Care 32 Suppl 1:S62–67, 2009). It is characterized by...
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Chapter
Bioengineered Vascularized Insulin Producing Endocrine Tissues
Islet transplantation is a promising treatment for type 1 diabetes (T1D), but limited islet engraftment hampers its success. In vivo, islets require time to remodel the hepatic parenchyma and establish their o...
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Article
Open AccessGenetic regulation of RNA splicing in human pancreatic islets
Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. Fo...
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Article
Open AccessA Multicenter Phase 2 Randomized Controlled Study on the Efficacy and Safety of Reparixin in the Treatment of Hospitalized Patients with COVID-19 Pneumonia
Acute lung injury and acute respiratory distress syndrome are common complications in patients with coronavirus disease 2019 (COVID-19). Poor outcomes in patients with COVID-19 are associated with cytokine rel...
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Article
Open AccessSeasonal Betacoronavirus Antibodies’ Expansion Post-BNT161b2 Vaccination Associates with Reduced SARS-CoV-2 VoC Neutralization
SARS-CoV-2 vaccination is known to induce antibodies that recognize also variants of concerns (VoCs) of the virus. However, epidemiological and laboratory evidences indicate that these antibodies have a reduce...
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Article
Correction to: Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy
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Article
Dysglycemia after COVID-19 pneumonia: a six-month cohort study
The aim of this study was to understand whether the dysglycemia associated with SARS-CoV-2 infection persists or reverts when the viral infection resolves.
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Article
Felix dies natalis, insulin… ceterum autem censeo “beta is better”
One hundred years after its discovery, insulin remains the life-saving therapy for many patients with diabetes. It has been a 100-years-old success story thanks to the fact that insulin therapy has continuousl...
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Article
Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy
Total pancreatectomy (TP) is a procedure weighed down not only by postoperative morbidity and mortality but also by long-term effects as a consequence of endocrine and exocrine pancreatic insufficiency. While ...
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Article
Open AccessAuthor Correction: PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
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Article
Open AccessThe hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells
Neonatal beta cells carry out a programme of postnatal functional maturation to achieve full glucose responsiveness. A partial loss of the mature phenotype of adult beta cells may contribute to a reduction of ...
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Article
Open AccessNeutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival
Understanding how antibody responses to SARS-CoV-2 evolve during infection may provide important insight into therapeutic approaches and vaccination for COVID-19. Here we profile the antibody responses of 162 ...
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Article
Total pancreatectomy as alternative to pancreatico-jejunal anastomosis in patients with high fistula risk score: the choice of the fearful or of the wise?
Patients with fistula risk score (FRS) ≥7 are at the highest risk of develo** clinically relevant post-operative pancreatic fistula (CR-POPF). There is no agreement on the management of this subpopulation. T...
