11 Result(s)
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Alessandra Petrelli
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Article
Open AccessMechanisms and risk factors of metabolic syndrome in children and adolescents
Metabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity, elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The diagnostic criteria for MetS in adult...
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Open AccessHOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives
We assessed whether HOMA-IR and the Matsuda Index are associated with transitions through stages of type 1 diabetes.
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Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at disease onset. A single AAb, sometimes at low titre, is often detected in some individuals, making t...
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Open AccessExocrine pancreas function is impaired in adult relatives of patients with type 1 diabetes
Alterations of the exocrine pancreas have been reported in type 1 diabetes, but their contribution to the pathogenesis of the disease is poorly understood. Here, we investigated markers of exocrine pancreas dy...
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Open AccessAutoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes
Diabetes mellitus can be categorized into two major variants, type 1 and type 2. A number of traits such as clinical phenotype, age at disease onset, genetic background, and underlying pathogenesis distinguish...
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Open AccessConserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation
Treg cells are critical regulators of immune homeostasis, and environment-driven Treg cell differentiation into effector (e)Treg cells is crucial for optimal functioning. However, human Treg cell programming i...
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Plasma circulating miR-23~27~24 clusters correlate with the immunometabolic derangement and predict C-peptide loss in children with type 1 diabetes
We aimed to analyse the association between plasma circulating microRNAs (miRNAs) and the immunometabolic profile in children with type 1 diabetes and to identify a composite signature of miRNAs/immunometaboli...
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New Evidence of Exocrine Pancreatopathy in Pre-symptomatic and Symptomatic Type 1 Diabetes
Type 1 diabetes (T1D) is one of the most frequent chronic autoimmune diseases in humans, characterized by the lack of insulin production resulting in high blood glucose levels and lifelong requirement of exoge...
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Open AccessRegulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression
Autoimmune type 1 diabetes (T1D) is thought to be caused by a defective immune regulation with regulatory T (Treg) cells playing a fundamental role in this process. Tolerance mechanisms depend on tunable respo...
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Open AccessDevelo** translational medicine professionals: the Marie Skłodowska-Curie action model
End goal of translational medicine is to combine disciplines and expertise to eventually promote improvement of the global healthcare system by delivering effective therapies to individuals and society. Well-t...
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CD8+ T cells in human autoimmune arthritis: the unusual suspects
CD8+ T-cell homeostasis is altered in the peripheral blood of patients with autoimmune arthritis
The close ...
