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Article
Open AccessAssessing changes in global fire regimes
The global human footprint has fundamentally altered wildfire regimes, creating serious consequences for human health, biodiversity, and climate. However, it remains difficult to project how long-term interact...
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Article
Open AccessProspective validation of VEGF and eNOS polymorphisms as predictors of first-line bevacizumab efficacy in patients with metastatic colorectal cancer
Bevacizumab (Bev) plus chemotherapy is a standard first-line treatment in metastatic colorectal cancer (mCRC), however to date no predictive factors of response have been identified. Results of our previous an...
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Article
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at disease onset. A single AAb, sometimes at low titre, is often detected in some individuals, making t...
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Article
Dysglycemia after COVID-19 pneumonia: a six-month cohort study
The aim of this study was to understand whether the dysglycemia associated with SARS-CoV-2 infection persists or reverts when the viral infection resolves.
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Article
Open AccessThe environment they lived in: anthropogenic changes in local and regional vegetation composition in eastern Fennoscandia during the Neolithic
Understanding about regional versus local changes in vegetation is critical in answering archaeological questions, in particular at a time when humans are assumed to have caused higher disturbances at local sc...
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Article
Early Gastric Cancer: identification of molecular markers able to distinguish submucosa-penetrating lesions with different prognosis
Early Gastric Cancer (EGC) reaches 25% of the gastric cancers surgically treated in some areas of Northeastern Italy and is usually characterized by a good prognosis. However, among EGCs classified according t...
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Mutational Analysis in Urinary Cell-Free DNA: KRAS in Colorectal Cancer
Urinary cell-free DNA offers an important noninvasive source of material for genomic testing also for nonurological tumors. Its clinical utility in monitoring tumor evolution and treatment failure is promising...
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Article
Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study
The aim of the study was to characterise the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with diabetes. Demonstrating the ability to mount an appropriate a...
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Article
Frequency of flash glucose monitoring readings, hemoglobin A1c and time in range: a real life study in adults with type 1 diabetes
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Off-label prescription of SGLT-2 inhibitors to patients with type 1 diabetes: an online survey of diabetes specialists in Italy
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Article
Open AccessImmunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients
In chronic lymphocytic leukemia (CLL) disease onset and progression are influenced by the behavior of specific CD4+ T cell subsets, such as T regulatory cells (Tregs). Here, we focused on the phenotypic and funct...
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Article
Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy: the AMD-Annals initiative
To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.
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Article
Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma
Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as meta...
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Article
Open AccessPromoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence
Epigenetic alterations of specific genes have been reported to be related to colorectal cancer (CRC) transformation and would also appear to be involved in the early stages of colorectal carcinogenesis. Little...
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Article
Open AccessDNA Methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach
Although non muscle invasive bladder cancer (NMIBC) generally has a good long-term prognosis, up to 80% of patients will nevertheless experience local recurrence after the primary tumor resection. The search f...
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Article
Open AccessGenomic alterations in rectal tumors and response to neoadjuvant chemoradiotherapy: an exploratory study
Neoadjuvant chemoradiotherapy is the treatment of choice in advanced rectal cancer, even though there are many patients who will not benefit from it. There are still no effective methods for predicting which p...
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Article
Predictors of Bone Responsiveness to Growth Hormone (GH) Replacement in Adult GH-Deficient Patients
Growth hormone (GH) replacement in adulthood results in variable bone responses as a function of the gonadic hormonal milieu. We performed a retrospective analysis of a large cohort of adult males and females ...
