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Article
Open AccessA brain-specific angiogenic mechanism enabled by tip cell specialization
Vertebrate organs require locally adapted blood vessels1,2. The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing ...
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Chapter and Conference Paper
Designing and Evaluating Generative AI-Based Voice-Interaction Agents for Improving L2 Learners’ Oral Communication Competence
Oral communication competence is an essential skill in 21st century society and workplaces. However, despite years of English learning, non-native learners often struggle to communicate with others in English ...
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Article
Facile microfluidic device for droplets emulsion from small samples
We presented a microfluidic device for the preparation of monodisperse microdroplets with a small volume of samples or reagents, which is power-free, user-friendly and based only on a highly portable syringe. ...
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Article
Junction matters in hydraulic circuit bio-design of microfluidics
Microfluidic channels are at micrometer scales; thus, their fluid flows are laminar, resulting in the linear dependence of pressure drop on flow rate in the length of the channel. The ratio of the pressure dro...
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Article
Elucidating the dynamics of polymer transport through nanopores using asymmetric salt concentrations
While notable progress has been made in recent years both experimentally and theoretically in understanding the highly complex dynamics of polymer capture and transport through nanopores, there remains signifi...
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Article
Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches
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Article
Open AccessADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial...
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Article
Specification of CNS macrophage subsets occurs postnatally in defined niches
All tissue-resident macrophages of the central nervous system (CNS)—including parenchymal microglia, as well as CNS-associated macrophages (CAMs1) such as meningeal and perivascular macrophages2–7—are part of the...
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Article
Open AccessDigital immunoassay for biomarker concentration quantification using solid-state nanopores
Single-molecule counting is the most accurate and precise method for determining the concentration of a biomarker in solution and is leading to the emergence of digital diagnostic platforms enabling precision ...
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Article
Open AccessCommon and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. Despite activating the same pathway, the BRAF V600E mutation and the prevalent mutations in codon 12 and 13 of KRAS have all...
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Article
A novel podocyte protein, R3h domain containing-like, inhibits TGF-β-induced p38 MAPK and regulates the structure of podocytes and glomerular basement membrane
Not only in kidney glomerular physiological function but also glomerular pathology especially in diabetic condition, glomerular podocytes play pivotal roles. Therefore, it is important to increase our knowledg...
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Article
Open Access-308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and metabolic syndrome susceptibility: a meta-analysis
Many studies tried to assess the relationship between -308G/A polymorphism of tumor necrosis factor alpha (TNF-α) gene and risk of metabolic syndrome (MS), but their results were contradictory. This meta-analysis...
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Article
1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grade gliomas
Tumor-associated macrophages (TAM)s are critical regulators of glioma progression. As yet, however, TAMs in isocitrate dehydrogenase (IDH) mutated lower-grade gliomas (LGGs) have not been thoroughly investigat...
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Article
One-step microdevices for synthesizing morphology-controlled ultraviolet-curable polysiloxane shell particles
Double emulsions have great potential application in many fields. Although many companies and research institutions have developed various strategies for forming double emulsions, production and stability are ...
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Article
Open AccessClinical characteristics on admission predict in-hospital fatal outcome in patients aged ≥75 years with novel coronavirus disease (COVID-19): a retrospective cohort study
Novel coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and precise fatality data by age group is needed urgently. This study to delineate the clinical characteristics and outcome of COVID-19...
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Article
Open AccessPublisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessSingle-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
Many important cell types in adult vertebrates have a mesenchymal origin, including fibroblasts and vascular mural cells. Although their biological importance is undisputed, the level of mesenchymal cell heter...
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Article
Open AccessTranscriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model
Renal interstitial fibrosis (RIF) is currently recognized as a crucial mechanism of the pathogenesis of chronic kidney disease (CKD). Kangxianling (KXL, anti-fibrin) is a traditional Chinese medicine that has ...
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Article
Open AccessRestoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression
The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent...
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Article
Open AccessReversible manipulation of the magnetic state in SrRuO3 through electric-field controlled proton evolution
Ionic substitution forms an essential pathway to manipulate the structural phase, carrier density and crystalline symmetry of materials via ion-electron-lattice coupling, leading to a rich spectrum of electron...
