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Article
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune effector cell-associated neurotoxicity syndrome (ICANS). However, the molecular mechanisms leading to ICANS are not well under...
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Article
Open AccessA community challenge to predict clinical outcomes after immune checkpoint blockade in non-small cell lung cancer
Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti–PD-1 Response Prediction DREAM Chal...
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Article
Open AccessMultiomic spatial landscape of innate immune cells at human central nervous system borders
The innate immune compartment of the human central nervous system (CNS) is highly diverse and includes several immune-cell populations such as macrophages that are frequent in the brain parenchyma (microglia) ...
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Article
Open AccessAn integrated tumor, immune and microbiome atlas of colon cancer
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, we performed comprehensive genomic anal...
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Article
Open AccessInsulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the central nervous system (CNS) and regulates neuronal survival and myelination in the adult CNS. In neuroinflammatory con...
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Article
Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches
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Article
Specification of CNS macrophage subsets occurs postnatally in defined niches
All tissue-resident macrophages of the central nervous system (CNS)—including parenchymal microglia, as well as CNS-associated macrophages (CAMs1) such as meningeal and perivascular macrophages2–7—are part of the...
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Article
Open AccessA scan for genes associated with cancer mortality and longevity in pedigree dog breeds
Selective breeding of the domestic dog (Canis lupus familiaris) rigidly retains desirable features, and could inadvertently fix disease-causing variants within a breed. We combine phenotypic data from > 72,000 do...
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Article
Open AccessA comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels
A deeper understanding of differences and similarities in transcriptional regulation between species can uncover important information about gene functions and the role of genes in disease. Deciphering such pa...
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Article
Expression of cell kinetics and death during monocyte–macrophage differentiation: effects of Actinomycin D and Vinblastine treatments
The different effects of two cytostatic drugs, Actinomycin D and Vinblastine, during macrophage-like differentiation induced in THP-1 monocytic cell line by phorbol ester phorbol 12-myristate 13-acetate (PMA) ...
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Article
Different apoptotic responses and patterns in adhering and floating neoplastic cell cultures: effects of microtubule antagonists
The relationship between apoptotic progression and cell cycle perturbation induced by microtubule-destabilising (vinblastine, Colcemid) and -stabilising (taxol) drugs was studied in two mesenchyme-derived neop...
