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Chapter
Fabricating Solid-State Nanopores for Single-Molecule Sensing
Solid-state nanopores are a technology poised to disrupt multiple critical fields, including but not limited to nucleic acid sequencing, proteomics, in vitro diagnostics, drug discovery, and next-generation in...
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Article
Elucidating the dynamics of polymer transport through nanopores using asymmetric salt concentrations
While notable progress has been made in recent years both experimentally and theoretically in understanding the highly complex dynamics of polymer capture and transport through nanopores, there remains signifi...
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Article
Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of the SMN1 gene and low SMN protein levels. Although lower motor neurons are a primary target, there is evidence that peripheral organ defe...
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Article
Open AccessDigital immunoassay for biomarker concentration quantification using solid-state nanopores
Single-molecule counting is the most accurate and precise method for determining the concentration of a biomarker in solution and is leading to the emergence of digital diagnostic platforms enabling precision ...
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Article
No small matter
The confined geometry of nanopores enables a wealth of chemistry and analysis to be conducted at the single-molecule scale. Yi-Lun Ying, Aleksandar P. Ivanov and Vincent Tabard-Cossa report on recent developme...
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Article
Open AccessSerum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis
Serum neurofilament light chain (NfL) is emerging as an important biomarker in multiple sclerosis (MS). Our objective was to evaluate the prognostic value of serum NfL levels obtained close to the time of MS o...
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Article
Solid-state nanopore fabrication by automated controlled breakdown
Solid-state nanopores are now well established as single-biomolecule sensors that hold great promise as sensing elements in diagnostic and sequencing applications. However, until recently this promise has been...
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Article
The potential and challenges of nanopore sequencing
A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a ...