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Article
Exploring functional relationships between components of the gene expression machinery
Eukaryotic gene expression requires the coordinated activity of many macromolecular machines including transcription factors and RNA polymerase, the spliceosome, mRNA export factors, the nuclear pore, the ribo...
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Article
Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy
Myotonic dystrophy is a CUG repeat expansion disease and mice deficient in MBNL1, an RNA binding protein, show many characteristics of the disease. Comparison of gene expression profiles of two mouse models of...
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Article
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
The authors identify brain RNA targets for TDP-43, a RNA binding protein linked to ALS. RNAs derived from genes with very long introns were more affected by TDP-43 levels. TDP-43 also auto-regulated its own sy...
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Article
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain
The Rbfox family of RNA binding proteins mediate alternative splicing. Douglas Black and colleagues show that targeted deletion of the mouse Rbfox1 gene in the CNS alters splice isoforms of a subset of genes and ...
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Article
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
In this study, the authors compare the RNA binding patterns of FUS/TLS and TDP-43. Although these proteins regulate the processing of mostly distinct gene products, they do show concurrent regulation of a subs...
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Article
Open AccessQuaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce trans...
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Article
Open AccessDistinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq ...
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Article
Open AccessOrigin and evolution of the octoploid strawberry genome
Cultivated strawberry emerged from the hybridization of two wild octoploid species, both descendants from the merger of four diploid progenitor species into a single nucleus more than 1 million years ago. Here...
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Article
Author Correction: Origin and evolution of the octoploid strawberry genome
In the version of this article originally published, author Joshua R. Puzey was incorrectly listed as having affiliation 7 (School of Plant Sciences, University of Arizona, Tucson, AZ, USA); affiliation 6 (Dep...
