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Chapter
Neuroendocrinology of Perinatal Mental Illness
Mental illness during pregnancy and the postpartum period is a growing health crisis. We know that at least 1 in 7 women during the perinatal period will experience a mood or anxiety disorder such as perinatal...
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Article
Open AccessGq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice
Patterned coordination of network activity in the basolateral amygdala (BLA) is important for fear expression. Neuromodulatory systems play an essential role in regulating changes between behavioral states, ho...
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Chapter
Mechanisms of Psychiatric Comorbidities in Epilepsy
Psychiatric illnesses, including depression and anxiety, are highly comorbid with epilepsy (for review see Josephson and Jetté (Int Rev Psychiatry 29:409–424, 2017), Salpekar and Mula (Epilepsy Behav 98:293–29...
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Article
Open AccessExperience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction
Learned fear and safety are associated with distinct oscillatory states in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC). To determine if and how these network states support the retrieval...
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Article
Cellular and oscillatory substrates of fear extinction learning
Davis et al. report that fear memories can be critically regulated by parvalbumin-expressing interneurons in the basolateral amygdala. Silencing these interneurons following fear memory extinction caused a reemer...
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Article
The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders
Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant lev...
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Chapter
GABAergic Control of the Hypothalamic–Pituitary–Adrenal (HPA) Axis: Role of Extrasynaptic GABAA Receptors
The body’s physiological response to stress is mediated by the hypothalamic–pituitary–adrenal (HPA) axis, the activity of which is tightly regulated by GABAergic inhibition. Parvocellular neurosecretory neuron...
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Article
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain
The Rbfox family of RNA binding proteins mediate alternative splicing. Douglas Black and colleagues show that targeted deletion of the mouse Rbfox1 gene in the CNS alters splice isoforms of a subset of genes and ...
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Reference Work Entry In depth
Premenstrual Dysphoric Disorder