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Article
Open AccessNew Horizons in Hyperpolarized 13C MRI
Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating new directions for research and applications with in vivo MR imaging and spectroscopy (MR...
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Protocol
Radiosynthesis of [18F]FPenM-C2Am: A PET Imaging Agent for Detecting Cell Death
Imaging agents capable of detecting the extent, timing, and distribution of tumor cell death following treatment could be used in clinical trials of novel cancer therapies to get an early indication of efficac...
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Article
Open AccessAuthor Correction: Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer
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Article
Open AccessHyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer
Hyperpolarised magnetic resonance imaging (HP 13C-MRI) is an emerging clinical technique to detect [1-13C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised [1-13C]pyruv...
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Article
Open AccessCorrection to: Multi-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessMulti-modal imaging of high-risk ductal carcinoma in situ of the breast using C2Am: a targeted cell death imaging agent
Ductal carcinoma in situ (DCIS) is a non-invasive form of early breast cancer, with a poorly understood natural history of invasive transformation. Necrosis is a well-recognized adverse prognostic feature of D...
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Article
Open AccessEditorial commentary for the special issue: technological developments in hyperpolarized 13C imaging—toward a deeper understanding of tumor metabolism in vivo
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Article
Open AccessProbing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR
To enhance detection of the products of hyperpolarized [2-13C]dihydroxyacetone metabolism for assessment of three metabolic pathways in the liver in vivo. Hyperpolarized [2-13C]DHAc emerged as a promising substra...
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Chapter
Innovating Metabolic Biomarkers for Hyperpolarized NMR
The aim of translational research is to identify biomarkers that could be used in clinical practice to improve diagnosis, prognostication, influence treatment options and monitor response to treatment. Magneti...
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Article
Open Access18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography
Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treat...
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Article
Open AccessMagnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T
Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time const...
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Article
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung
Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated su...
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Article
Spectroscopic measurements of metabolic fluxes
The conversion of a deuterated substrate into cellular metabolites in vivo can be quantified via decreases in the proton nuclear magnetic resonance signals of these metabolites.
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Article
Reply to ‘Assembling the brain trust: the multidisciplinary imperative in neuro-oncology’
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Open AccessChallenges to curing primary brain tumours
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique...
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Article
Open AccessGlyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal
Methylglyoxal is a faulty metabolite. It is a ubiquitous by-product of glucose and amino acid metabolism that spontaneously reacts with proximal amino groups in proteins and nucleic acids, leading to impairmen...
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Article
Open AccessImaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the d...
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Article
MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter
Urea transporter can be used as a sensitive, contrast agent-free gene reporter for magnetic resonance imaging in cells and whole animals.
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Article
Open AccessDetection of colorectal dysplasia using fluorescently labelled lectins
Colorectal cancer screening using conventional colonoscopy lacks molecular information and can miss dysplastic lesions. We tested here the ability of fluorescently labelled lectins to distinguish dysplasia fro...
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Article
Open AccessIdentifying active vascular microcalcification by 18F-sodium fluoride positron emission tomography
Vascular calcification is a complex biological process that is a hallmark of atherosclerosis. While macrocalcification confers plaque stability, microcalcification is a key feature of high-risk atheroma and is...
