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Article
Open AccessAssociations between back pain across adulthood and spine shape in early old age in a British birth cohort
We aimed to examine whether back pain across adulthood was associated with spine shape at age 60–64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally re...
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Chapter and Conference Paper
Classification of Osteoporotic Vertebral Fractures Using Shape and Appearance Modelling
Osteoporotic vertebral fractures (VFs) are under-diagnosed, creating an opportunity for computer-aided, opportunistic fracture identification in clinical images. VF diagnosis and grading in clinical practice i...
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Article
Open AccessImaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the d...
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Chapter and Conference Paper
Automatic Localisation of Vertebrae in DXA Images Using Random Forest Regression Voting
We describe a method for automatic detection and localisation of vertebrae in clinical images that was designed to avoid making a priori assumptions of how many vertebrae are visible. Multiple random forest regre...
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Chapter and Conference Paper
Fully Automatic Localisation of Vertebrae in CT Images Using Random Forest Regression Voting
We describe a system for fully automatic vertebra localisation and segmentation in 3D CT volumes containing arbitrary regions of the spine, with the aim of detecting osteoporotic fractures. To avoid the diffic...
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Article
Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes
We report clinical findings, bone mineral density (BMD) and bone biopsy data in ten children with features of classic idiopathic juvenile osteoporosis (IJO). We also screened the patients for mutations in LRP5 an...
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Article
Advances in bone imaging for osteoporosis
The diagnosis and monitoring of osteoporosis have been improved by the development of new methods for undertaking skeletal assessment. A number of imaging methods exist and all have advantages and disadvantage...
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Article
Open AccessInfluence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men
We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r ...
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Article
Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study
The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men ...
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Article
Open AccessA validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the...
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Article
Open AccessRadiation exposure in X-ray-based imaging techniques used in osteoporosis
Recent advances in medical X-ray imaging have enabled the development of new techniques capable of assessing not only bone quantity but also structure. This article provides (a) a brief review of the current X...
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Article
Influence of Lifestyle Factors on Quantitative Heel Ultrasound Measurements in Middle-Aged and Elderly Men
We examined the distribution of quantitative heel ultrasound (QUS) parameters in population samples of European men and looked at the influence of lifestyle factors on the occurrence of these parameters. Men a...
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Chapter and Conference Paper
Segmentation of Lumbar Vertebrae Using Part-Based Graphs and Active Appearance Models
The aim of the work is to provide a fully automatic method of segmenting vertebrae in spinal radiographs. This is of clinical relevance to the diagnosis of osteoporosis by vertebral fracture assessment, and to...
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Article
Application of a Triage Approach to Peripheral Bone Densitometry Reduces the Requirement for Central DXA but is not Cost Effective
A method proffered for the interpretation of measurements from peripheral dual energy X-ray absorptiometry (pDXA) is a triage approach to stratify patients into one of three risk categories; (i) high-treat, (i...
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Article
Radiologic assessment of osteoporotic vertebral fractures: diagnostic and prognostic implications
As populations age osteoporosis becomes an increasingly important public health issue. Among osteoporotic fractures vertebral fractures are of particular relevance: they are the most common fractures, frequent...
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Chapter and Conference Paper
Automatic measurement of vertebral shape using Active Shape Models
In this paper, we describe how Active Shape Models (ASMs) have been used to accurately and robustly locate vertebrae in noisy lateral Dual Energy X-ray Absorptiometry (DXA) images of the spine. Vertebrae were ...
