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Article
Mismatch in how oestrogen modulates molecular and neuronal function may explain menstrual migraine
This paper is designed to provide concepts and stimulate directions for further investigation of menstrual migraine. On the basis of experimental studies and literature review, we propose that abnormalities in...
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Article
Research developments in the physiopathology of primary headaches
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Article
Concepts of migraine headache pathogenesis: insights into mechanisms of chronicity and new drug targets
The pathophysiology of migraine is incompletely understood. Neurobiological and gene regulation studies and advanced brain imaging are providing new insights into migraine pathogenesis. Recent discoveries hav...
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Chapter
Mitochondrial Disorder and Migraine
The classification of migraine includes typical headache without aura of neuro-logic deficit (previously termed common migraine; International Headache Society [IHS] classification 1.1) and headache associated wi...
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Chapter
Cellular and Metabolic Significance of Cellular Acid-Base Shifts in Human Stroke
Stroke is most often due to the occlusion of a single intracranial artery, resulting in incomplete focal ischemia. This has an immediate deleterious effect upon cerebral energy metabolism and dependent process...
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Article
Chronic changes in brain Mg2+ concentration after forebrain ischemia in the rat
Brain Mg2+ ion concentrations, [Mg2+], were evaluated in three groups of animals subjected to either 8 minutes (n=10), or 12 minutes (n=10) of near-complete forebrain ischemia, or sham operation (n=10), from thei...
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Chapter
31P in vivo Spectroscopy of Adult Human Brain
Nuclear Magnetic Resonance (NMR) in condensed matter was discovered more than three decades. Since then, it has proven to be a fundamental and invaluable tool in the fields of chemistry and physics. Only withi...
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Chapter
Magnetic Observation of Spreading Cortical Depression in Anaesthetized Rabbits
Spreading depression (SD) is a profound disturbance of the environment of brain cells that occurs as a stereotyped response to several types of strong stimulation or trauma (for reviews see e.g. Bures et al., ...
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Chapter
Observation of Spreading Cortical Depression in Migraine Patients
Spreading cortical depression (SCD) in animal models was first described by Leao [1] in 1944. SCD, although never observed spontaneously in humans, has been implicated in migraine for a variety of reasons: 1) ...
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Chapter
Are Heart Attacks Really Brain Attacks?
In 1664, Thomas Willis recognized that the brain and the cardiovascular system are interdependent-when he wrote De Anatome Cerebri (Willis 1664). For the relief of angina pain, Francois Franck, in 1899, proposed ...
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Chapter and Conference Paper
Photoactivation of Hematoporphyrin Derivative in Cat Brain: A Model of Ischemic Necrosis
Hematoporphyrin derivative (HpD) is under investigation as a phototherapeutic agent for the treatment of cerebral neoplasia (McCulloch et al, 1983). When illuminated with red light (wavelength 631 nm) in the p...
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Chapter
The Influence of Serotonin on Seizure Susceptibility in the Gerbil
5-hydroxytryptophan (5-HTP) (50 mg/kg, I.P.) increased central serotonin (5-HT) levels and delayed the onset of seizure during reflow in gerbils subjected to transient bilateral blockade with dimethyl tryptami...
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Chapter
Reemphasis of the Role of 5-Hydroxytryptamine in Cerebral Ischemia
Cortical monoamine changes during ischemic episodes of up to one hour were studied in the gerbil. Norepinephrine (NE) levels decreased after 60 minutes in the occluded hemisphere of animals with stroke, but do...
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Chapter and Conference Paper
Contribution of Platelet Aggregation and Serotonin Release to Progressive Cerebral Infarction
Prevention and amelioration of acute cerebral infarction resulting from occlusion of the aortocerebral arterial circulation is best effected by maintenance of tissue metabolic viability by enhancing the cerebr...
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Chapter and Conference Paper
The Role of Biogenic Amines in the Progression of Cerebral Ischemia and Edema: Modification by p-Chlorophenylalanine, Methysergide, and Pentoxyfilline
Disorders of monoamine neurotransmitter metabolism, particularly 5-hydroxytryptamine and dopamine, may play some part in the early development of edema and in the progression of ischemia. This early edema seem...
