Abstract
Spreading depression (SD) is a profound disturbance of the environment of brain cells that occurs as a stereotyped response to several types of strong stimulation or trauma (for reviews see e.g. Bures et al., 1974; Nicholson & Kraig, 1981). It can propagate in some circumstances in a non-decrementing, regenerative, wave through susceptible tissue at speeds of 2–5mm/min, causing transient disturbances of function at each site for a minute or more. There are many points of similarity between the characteristics of SD in animals and the disturbances associated with classical migraine in man (Leao & Momson, 1945; Milner, 1958; Gardner-Medwin, 1981; Lauritzen & Olesen, 1984). Magnetic fields associated with SD were first demonstrated using isolated tissue from the turtle cerebellum (Okada et al. 1988). We have studied fields during propagation of SD through the cerebral cortex of the anaesthetised rabbit. Such studies are of interest primarily because they may offer points of comparison with magnetic events studied during migraine in man (Tepley et al., 1989).
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References
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© 1989 Plenum Press, New York
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Gardner-Medwin, A.R. et al. (1989). Magnetic Observation of Spreading Cortical Depression in Anaesthetized Rabbits. In: Williamson, S.J., Hoke, M., Stroink, G., Kotani, M. (eds) Advances in Biomagnetism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0581-1_67
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DOI: https://doi.org/10.1007/978-1-4613-0581-1_67
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