Abstract
Spreading cortical depression (SCD) in animal models was first described by Leao [1] in 1944. SCD, although never observed spontaneously in humans, has been implicated in migraine for a variety of reasons: 1) the marked dilation of pial blood vessels accompanying SCD [2], 2) the slow propagation speed of 3 mm/min which is comparable to the motion of migraine scotomata [3] and 3) the cerebral blood flow anomolies observed in migraine with aura which are also similar to those seen during SCD [4]. SCD is not observable by surface EEG, but Okada et al [5, 6] produced SCD in isolated turtle cerebellum by electrical stimulation and recorded biphasic slow magnetic waves. They suggested SCD should be observable by MEG in humans. We report here the results of studies on migraine patients, normal subjects and patients suffering non-migraine headaches.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Leao, A.A.P., 1944, Spreading cortical depression of activity in the cerebral cortex, J Neurophysiol, 7: 379–390.
Leao, A.A.P., Morrison, R.S, 1945, Propagation of spreading cortical depression, J Neurophysiol, 8: 33–45.
Milner, P.M., 1958, Note on a possible correspondence between scotomas of migraine and spreading depression of Leao. EEG Clin Neurophysiol, 10: 705.
Lauritzen, M., 1987, Cortical spreading depression as a putative migraine mechanism, Trends Neurosci, 10: 8–13.
Okada, Y.C., Nicholson, C., 1988, DC-coupled single trial measurements of the magnetic field during spreading depression in the cerebellum. In: Biomagnetism’87, Atsumi K, Kotani M, Ueno S, Katila T, Williamson SJ (eds.), Denki University Press, London, 1988, pp. 202–205.
Okada, Y., Lauritzen, M., Nicholson, C., 1988, Magnetic field associated with spreading cortical depression: a model for the detection of migraine, Brain Research, 442: 185–190.
Moran, J.E., Tepley, N., (submitted for publication) Data Period Analysis - a rapid method for recognizing changes of alertness in MEG and EEG data.
Hjorth, B., 1970, EEG analysis based on time domain properties. EEG Clin Neurophysiol 29: 306–310.
Gardner-Medwin, A.R., Tepley, T., Barkley, G.L., Moran, J., Nagel- Leiby, S., Simkins, R.T., Welch, K.M.A., Magnetic observation of spreading cortical depression in anesthetized rabbits. This volume.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Tepley, N., Barkley, G.L., Moran, J.E., Simkins, R.T., Welch, K.M.A. (1989). Observation of Spreading Cortical Depression in Migraine Patients. In: Williamson, S.J., Hoke, M., Stroink, G., Kotani, M. (eds) Advances in Biomagnetism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0581-1_68
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0581-1_68
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7876-4
Online ISBN: 978-1-4613-0581-1
eBook Packages: Springer Book Archive