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The Role of Biogenic Amines in the Progression of Cerebral Ischemia and Edema: Modification by p-Chlorophenylalanine, Methysergide, and Pentoxyfilline

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Dynamics of Brain Edema

Summary

Disorders of monoamine neurotransmitter metabolism, particularly 5-hydroxytryptamine and dopamine, may play some part in the early development of edema and in the progression of ischemia. This early edema seems potentially reversible if ischemia is relieved but continued ischemia leads to profound depletion of monoamine neurotransmitters and cyclic AMP in brain, coupled with progressive edema.

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References

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Author information

Authors and Affiliations

  1. Department of Neurology, Baylor College of Medicine, Houston, Tx., USA

    K. M. A. Welch, E. Chabi, R. F. Dodson, T.-P. F. Wang, J. Nell & B. Bergin

  2. Baylor-Methodist Center for Cerebrovascular Research, Houston, Tx., USA

    K. M. A. Welch, E. Chabi, R. F. Dodson, T.-P. F. Wang, J. Nell & B. Bergin

Authors
  1. K. M. A. Welch
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  2. E. Chabi
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  3. R. F. Dodson
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  4. T.-P. F. Wang
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  5. J. Nell
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  6. B. Bergin
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Editor information

Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Welch, K.M.A., Chabi, E., Dodson, R.F., Wang, TP.F., Nell, J., Bergin, B. (1976). The Role of Biogenic Amines in the Progression of Cerebral Ischemia and Edema: Modification by p-Chlorophenylalanine, Methysergide, and Pentoxyfilline. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_32

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  • DOI: https://doi.org/10.1007/978-3-642-66524-0_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08009-1

  • Online ISBN: 978-3-642-66524-0

  • eBook Packages: Springer Book Archive

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