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  1. No Access

    Article

    Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase

    This review is focused on gender differences in cardiac remodeling secondary to sustained increases in cardiac volume (VO) and generated pressure (PO). Estrogen has been shown to favorably alter the course of ...

    Joseph S. Janicki, Francis G. Spinale… in Pflügers Archiv - European Journal of Phys… (2013)

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    Chapter

    Introduction

    To meet the metabolic requirements of the body over a wide range of physical activity, the heart must be capable of increasing its cardiac output seven-to eightfold. This is accomplished by acute increases in ...

    Joseph S. Janicki, Masatsugu Hori… in Cardiac-Vascular Remodeling and Functional… (1997)

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    Chapter

    Myocardial Interstitial Collagen Matrix Remodeling in Response to a Chronic Elevation in Ventricular Preload or Afterload

    Fibrillar collagen is an essential component of the extracellular matrix of the heart that surrounds and interconnects the coronary microcirculation, individual myocytes, groups of cardiac myofibrils, muscle f...

    Joseph S. Janicki, Scott E. Campbell… in Cardiac-Vascular Remodeling and Functional… (1997)

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    Chapter

    Structural and Functional Consequences of Myocardial Collagen Remodeling

    Myocardial fibrillar collagens provide for muscle fiber and cardiac myocyte alignment and impart a tensile strength to the myocardium that maintains ventricular shape and size, and governs tissue stiffness. Th...

    Joseph S. Janicki, Suresh C. Tyagi, Beatriz B. Matsubara… in Cardiac Adaptation and Failure (1994)

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    Chapter

    Left Ventricular Systolic Resistance and Its Role in Coupling the Ventricle to the Arterial Circulation

    The overall performance of the left ventricle coupled to the arterial circulation is dependent on the intrinsic mechanical properties of the individual subsystems and their mutual interaction. The myocardium o...

    Sanjeev G. Shroff, Joseph S. Janicki, Karl T. Weber in Ventricular/Vascular Coupling (1987)

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    Chapter

    Influence of Extracardiac Forces on the Cardiopulmonary Unit

    The cardiopulmonary unit consists of the heart and lungs. It is responsible for the transport and exchange of oxygen and carbon dioxide between the metabolizing tissues and the atmosphere (Weber et al. 1983). ...

    Joseph S. Janicki, Sanjeev G. Shroff, Karl T. Weber in Ventricular/Vascular Coupling (1987)