130 Result(s)

Article

Prevalence of the Japanese high bleeding risk criteria and its prognostic significance for fatal bleeding in patients with acute myocardial infarction

The Japanese high-bleeding-risk criteria (Japanese-HBR), modified criteria of the Academic Research Consortium (ARC) HBR, has been recently proposed. We aimed to investigate the prevalence of the ARC-HBR and t...

Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Shinichiro Suna… in Heart and Vessels (2021)

Article

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we conducted a large-scale genome-wide association study of 168,228 individuals of Japanese ancestry (25,892 cases and 142...

Satoshi Koyama, Kaoru Ito, Chikashi Terao, Masato Akiyama… in Nature Genetics (2020)

Article

Protein Quality Control Dysfunction in Cardiovascular Complications Induced by Anti-Cancer Drugs

Cardiovascular complications, including heart failure, hypertension, ischemic syndromes and venous thromboembolism, have been identified in patients treated with anti-cancer drugs. Oxidative stress, mitochondr...

Hai Ying Fu, Mikio Mukai, Nobuhisa Awata… in Cardiovascular Drugs and Therapy (2017)

Article

Efficacy and safety of bisoprolol fumarate compared with carvedilol in Japanese patients with chronic heart failure: results of the randomized, controlled, double-blind, Multistep Administration of bisoprolol IN Chronic Heart Failure II (MAIN-CHF II) study

Bisoprolol fumarate (bisoprolol) is a β-blocker widely used to treat chronic heart failure (CHF). However, few studies have compared its efficacy and safety with those of the widely used β-blocker carvedilol i...

Masatsugu Hori, Ryozo Nagai, Tohru Izumi, Masunori Matsuzaki in Heart and Vessels (2014)

Article

A Lucky Find in AF Trials – a decrease in ICH with new OACs

Masatsugu Hori in Current Cardiovascular Risk Reports (2012)

Article

Efficacy and Safety of Tolvaptan in Heart Failure Patients with Sustained Volume Overload despite the Use of Conventional Diuretics: A Phase III Open-Label Study

Volume overload is a common complication associated with heart failure (HF) and is recommended to be treated with loop or thiazide diuretics. However, use of diuretics can cause serum electrolyte imbalances an...

Masatake Fukunami, Masunori Matsuzaki, Masatsugu Hori… in Cardiovascular Drugs and Therapy (2011)

Article

Phase III Clinical Pharmacology Study of Tolvaptan

This study aimed to investigate the pharmacokinetics, pharmacodynamics, efficacy and safety of tolvaptan, an orally effective vasopressin V2-receptor antagonist.

Takayuki Inomata, Tohru Izumi, Masunori Matsuzaki… in Cardiovascular Drugs and Therapy (2011)

Article

Efficacy and Safety of Tolvaptan in Heart Failure Patients with Volume Overload Despite the Standard Treatment with Conventional Diuretics: A Phase III, Randomized, Double-blind, Placebo-controlled Study (QUEST Study)

Diuretics are recommended to treat volume overload with heart failure (HF), however, they may cause serum electrolyte imbalance, limiting their use. Moreover, patients with advanced HF could poorly respond to ...

Masunori Matsuzaki, Masatsugu Hori, Tohru Izumi… in Cardiovascular Drugs and Therapy (2011)

Article

Effects of Tolvaptan on Volume Overload in Japanese Patients with Heart Failure: Results of a Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study

Tolvaptan may reduce the signs of volume overload in heart failure (HF) patients who experience volume overload despite using conventional diuretics. In this study, we evaluated the dose-response effects of to...

Masunori Matsuzaki, Masatsugu Hori, Tohru Izumi… in Cardiovascular Drugs and Therapy (2011)

Article

SNPs in BRAP associated with risk of myocardial infarction in Asian populations

Toshihiro Tanaka and colleagues report the identification of variants in BRAP, which encodes a galectin-2–binding protein, that are associated with risk of myocardial infarction in two Asian populations.

Kouichi Ozaki, Hiroshi Sato, Katsumi Inoue, Tatsuhiko Tsunoda… in Nature Genetics (2009)

Article

Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a trea...

Shigeru Miyagawa, Goro Matsumiya, Toshihiro Funatsu, Masao Yoshitatsu… in Surgery Today (2009)