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Article
Matrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling
Following myocardial infarction (MI), maladaptive upregulation of matrix metalloproteinase (MMP) alters extracellular matrix leading to cardiac remodeling. Intramyocardial hydrogel delivery provides a vehicle ...
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Article
Open AccessInterpretable machine learning predicts cardiac resynchronization therapy responses from personalized biochemical and biomechanical features
Cardiac Resynchronization Therapy (CRT) is a widely used, device-based therapy for patients with left ventricle (LV) failure. Unfortunately, many patients do not benefit from CRT, so there is potential value i...
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Article
Heart failure as interstitial cancer: emergence of a malignant fibroblast phenotype
A prolonged state of left ventricular pressure overload, commonly caused by hypertension and aortic valve disease, promotes remodelling of the myocardium that can progress to heart failure with preserved eject...
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Article
Speckle-Tracking Echocardiography Enables Model-Based Identification of Regional Stiffness Indices in the Left Ventricular Myocardium
Left ventricular (LV) remodeling is a critical process underlying heart failure (HF) development and progression. While LV global longitudinal strain determined by speckle-tracking echocardiography (STE) provi...
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Article
Open AccessThe Effects of Regular Exercise on Circulating Cardiovascular-related MicroRNAs
The purpose of the present study was to examine the effects of regular exercise on the abundance of targeted circulating microRNAs (miRNAs). The present analysis examined 20 previously sedentary adults from th...
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Article
Open AccessUse of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines
Anthracycline induced cardiomyopathy is a major cause of mortality and morbidity among pediatric cancer survivors. It has been postulated that oxidative stress induction and inflammation may play a role in the...
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Article
Sonomicrometry-Based Analysis of Post-Myocardial Infarction Regional Mechanics
Following myocardial infarction (MI), detrimental changes to the geometry, composition, and mechanical properties of the left ventricle (LV) are initiated in a process generally termed adverse post-MI remodeli...
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Article
Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition
Inhibitors of matrix metalloproteinases (MMPs) have been extensively explored to treat pathologies where excessive MMP activity contributes to adverse tissue remodelling. Although MMP inhibition remains a rele...
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Article
Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion
Atrial fibrosis is considered to contribute to atrial fibrillation (AF) recurrence following cardioversion. This study tested the hypothesis that circulating levels of matrix metalloproteinases (MMPs) and tiss...
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Article
Biomarkers and Heart Disease: What is Translational Success?
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Article
Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase
This review is focused on gender differences in cardiac remodeling secondary to sustained increases in cardiac volume (VO) and generated pressure (PO). Estrogen has been shown to favorably alter the course of ...
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Article
Cardiac Function and Circulating Cytokines After Endotoxin Exposure in Neonatal Mice
Complications after cardiac surgery in neonates can occur because of activation of the inflammatory system. This study used lipopolysaccharide (LPS) endotoxin exposure to cause cytokine activation in neonatal ...
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Article
Open AccessRegional matrix metalloproteinase activation correlates with microstructure diffusion tensor indices post myocardial infarction
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Article
Matrix metalloproteinase therapy in heart failure
Milestones in the progression to heart failure following myocardial infarction (MI) are changes in left ventricular (LV) geometry and function, termed post-MI remodeling. Critical to this adverse remodeling pr...
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Article
Open AccessCharacterization of myocardial remodeling with diffusion tensor magnetic resonance imaging in chronic porcine model using the toroid-based representation
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Article
Infarct Size Reduction and Attenuation of Global Left Ventricular Remodeling with the CorCapTM Cardiac Support Device Following Acute Myocardial Infarction in Sheep
Background:Whether mechanical restraint of the left ventricle (LV) can influence remodeling following myocardial infarction (MI) remains poorly understood. The following discussion details three studies examining...
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Matrix Metalloproteinases and Myocardial Remodeling
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Article
Introduction to Special Issue on The Matrix Metalloproteinases: New Insights into Myocardial Remodeling
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Article
Large animal models of congestive heart failure: A critical step in translating basic observations into clinical applications
Congestive heart failure (CHF) is a clinical syndrome in which pathophysiologic underpinnings include left ventricular (LV) dysfunction, remodeling, and increased neurohormonal activation. Accordingly, large a...
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Chapter
Matrix metalloproteinases in heart failure: evidence from experimental models
The LV myocardial remodeling process invariably occurs with the development and progression of congestive heart failure (CHF). LV remodeling is a multi-cellular process that results in abnormalities in LV myoc...
