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Article
Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: A marker of cardiac dilatation
Background: Idiopathic dilated cardiomyopathy (DCM), ventricular systolic dysfunction and chamber dilatation are accompanied by architectural remodeling, wall thinning and cardiac myocyte slippage. Recent work h...
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Article
The upregulation of endothelin and its receptors in porcine coronary arteries in a double balloon injury model of restenosis
Endothelin, a potent vasoconstrictor, mitogen, and stimulant of collagen synthesis, is reported to be increased after vascular injury. We tested the hypothesis that tissue endothelin levels and its receptor e...
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Article
Acute knee trauma: how many plain film views are necessary for the initial examination?
Objective. To determine whether anteroposterior (AP) and lateral views of the knee are equivalent to four views in acute fracture detection. Design. Three musculoskeletal radiologists retrospectively interpreted...
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Chapter
Myocardial Interstitial Collagen Matrix Remodeling in Response to a Chronic Elevation in Ventricular Preload or Afterload
Fibrillar collagen is an essential component of the extracellular matrix of the heart that surrounds and interconnects the coronary microcirculation, individual myocytes, groups of cardiac myofibrils, muscle f...
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Article
Immediate postnatal rat heart development modified by abdominal aortic banding: Analysis of gene expression
Proliferative growth of the ventricular myocyte (cardiomyocyte) is primarily limited to embryonic, fetal and very early neonatal periods of heart development. In contrast, cardiomyocyte maturation, as evidence...
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Article
Matrix metalloproteinase activity expression in infarcted, noninfarcted and dilated cardiomyopathic human hearts
In the normal myocardium matrix metalloproteinases (MMP) are present in the latent form. To examine whether MMP are activated following infarction or idiopathic dilated cardiomyopathy (DCM), we extracted and m...
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Chapter
Immediate postnatal rat heart development modified by abdominal aortic banding: Analysis of gene expression
Proliferative growth of the ventricular myocyte (cardiomyocyte) is primarily limited to embryonic, fetal and very early neonatal periods of heart development. In contrast, cardiomyocyte maturation, as evidence...
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Chapter
Progressive Ventricular Dilatation in Heart Failure: The Role of Myocardial Collagenase
Fibrillar collagen is an integral component of the extracellular matrix of the heart, linking the numerous myocardial components and ensuring an efficient functioning organ. Specifically it provides for muscle...
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Chapter
Diastolic Dysfunction in Chronic Pressure and Volume Overload
To maintain cardiac pump function, concentric hypertrophy develops in chronic pressure and eccentric hypertrophy in chronic volume overload states. Although with respect to systolic function myocardial hypertr...
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Chapter
Structural and Functional Consequences of Myocardial Collagen Remodeling
Myocardial fibrillar collagens provide for muscle fiber and cardiac myocyte alignment and impart a tensile strength to the myocardium that maintains ventricular shape and size, and governs tissue stiffness. Th...
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Chapter
Myocardial Fibrosis: Structural Basis for Diastolic Dysfunction
Left ventricular hypertrophy (LVH) is the single most important prognostic factor associated with adverse cardiovascular events, including heart failure and sudden death, attributable to cardiovascular disease...
