-
Article
Open AccessAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK...
-
Article
Open AccessStructural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can p...
-
Article
Open AccessAllosteric control of Ubp6 and the proteasome via a bidirectional switch
The proteasome recognizes ubiquitinated proteins and can also edit ubiquitin marks, allowing substrates to be rejected based on ubiquitin chain topology. In yeast, editing is mediated by deubiquitinating enzym...
-
Article
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice
The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific membrane lysis. Although ...
-
Article
Open AccessHIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck
Nef is an HIV-1 accessory protein essential for viral replication and AIDS progression. Nef interacts with a multitude of host cell signaling partners, including members of the Src kinase family. Nef preferent...
