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    Article

    Covalent inhibition of pro-apoptotic BAX

    BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. In response to cellular stress, B...

    Matthew W. McHenry, Peiwen Shi, Christina M. Camara in Nature Chemical Biology (2024)

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    Open Access

    Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency

    Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can p...

    Michelle S. Prew, Christina M. Camara, Thomas Botzanowski in Nature Communications (2022)