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    Article

    Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

    The clinical translation of cationic α-helical antimicrobial peptides (AMPs) has been hindered by structural instability, proteolytic degradation and in vivo toxicity from nonspecific membrane lysis. Although ...

    Rida Mourtada, Henry D. Herce, Daniel J. Yin, Jamie A. Moroco… in Nature Biotechnology (2019)

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    Article

    Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations

    To create a new class of mitochondria-penetrating peptides (MPPs) that would facilitate drug delivery into the organelle through the inclusion of delocalized lipophilic cations (DLCs) in the peptide sequence.

    Shana O. Kelley, Kelly M. Stewart, Rida Mourtada in Pharmaceutical Research (2011)