Skip to main content

2 Result(s)

within Murugappan Sathappa Remove this filter

and

  1. Article

    Open Access

    Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

    PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK...

    Peter G. Miller, Murugappan Sathappa, Jamie A. Moroco, Wei Jiang… in Nature Communications (2022)

    Download PDF (4390 KB) View Article

  2. No Access

    Article

    Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

    The mitochondrial inner membrane generates a proton-motive force (PMF) that drives cellular processes. Using a high-resolution fluorescence map** approach combined with kinetic analyses, changes in the PMF a...

    Ketan Malhotra, Murugappan Sathappa… in Nature Structural & Molecular Biology (2013)