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Article
Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity
The biotransformation of several analogs of the anti-calcium agent bepridil was studied comparatively in liver cells isolated from one rat. Three types of metabolites were identified by mass spectrometry, resu...
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Article
N-Dephenylated and N-phenyl urinary metabolites of mociprazine (CERM 3517) in beagle dogs after oral administration. A mass spectrometric determination
CERM 3S17 (mociprazine), a new anti-emetic compound, was administered orally to six beagle dogs at 10 mg/kg b.i.d. for four days. Unconjugated urinary metabolites were identified by GC-MS analysis against synt...
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Article
Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man
The bioavailability of two oral formulations of trimipramine, tablets and solution, was performed in twelve healthy volunteers, in a cross-over study. Each formulation was administered in the morning after a f...
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Article
Kinetics of metapramine and its demethylated metabolites after single and chronic oral administration in man
The kinetics of metapramine and two of its demethylated metabolites were determined in six normal subjects after oral administration of a single 150 mg dose on day 1 and 3 × 50 mg dose on day 2–6. This study h...
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Article
Pharmacokinetic study of3H-labelled PAF-acether II. Comparison with3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding
The blood and plasma kinetics of intravenously administered3H-labelled PAF-acether were determined in seven rabbits. PAF-acether was rapidly distributed and slowly eliminated. Individual variations were very smal...
