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Article
Urinary elimination of salsolinol enantiomers in alcoholics
The analysis of the urine from 6 chronic alcoholics showed that (R)-and (S)-salsolinol were detectable in 4 subjects, the R enantiomer was only found in one and that both enantiomers were under the limit of de...
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Article
Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects
The R enantiomer of salsolinol was detected in the urine of two out of six healthy subjects, whereas 1,2-dehydrosalsolinol was present in the urine of all the subjects. (S)-salsolinol was never detected. Admin...
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Chapter
Urinary excretion of salsolinol enantiomers and 1,2-dehydrosalsolinol in patients with degenerative dementia
The daily urinary excretion of total (R)- and (S)-salsolinol and 1,2-dehydrosalsolinol (free + sulfoconjugate) was measured in patients with degenerative dementia. (R)-Salsolinol was detectable in the urine of...
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Chapter
Salsolinol and the early detection of Parkinson’s disease
In a previous study, the daily urinary excretion of total (R + S) salsolinol was shown to be significantly lower in de novo parkinsonian patients than in healthy volunteers.
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Article
Enantiomeric composition of urinary salsolinol in Parkinsonian patients after Madopar
Urinary salsolinol output had been shown to be lower in Parkinsonian patients than in controls and to increase largely after L-dopa therapy. It had also been established that the R enantiomer of salsolinol is ...
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Article
Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man
The bioavailability of two oral formulations of trimipramine, tablets and solution, was performed in twelve healthy volunteers, in a cross-over study. Each formulation was administered in the morning after a f...
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Article
Urinary excretion of salsolinol enantiomers in patients with degenerative dementia
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Article
Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases
Tetrahydroisoquinoline (TIQ) alkaloids and 1-carboxy TIQ derivatives have been found in human fluids and/or tissues. The possible biosynthetic pathways of salsolinol (Sal), taken as an example of TIQs, are dis...
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Chapter and Conference Paper
Methodology of a Controlled Trial in Alzheimer’s Disease
Various evaluation scales suggested for studying the clinical evolution of Alzheimer-type dementias are discussed, and the practical aspects of a controlled clinical trial are considered.
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Article
Kinetics of metapramine and its demethylated metabolites after single and chronic oral administration in man
The kinetics of metapramine and two of its demethylated metabolites were determined in six normal subjects after oral administration of a single 150 mg dose on day 1 and 3 × 50 mg dose on day 2–6. This study h...
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Article
Effect of a reversible and selective MAO-A inhibitor (cimoxatone) on diurnal variation in plasma prolactin level in man
Prolactin (PRL) secretion is stimulated by serotonin (5-HT) and inhibited by dopamine (DA). 5-HT is generally recognized as a substrate for type A monoamine oxidase (MAO), whereas DA is considered as a substra...
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Article
The frequency of relapse in multiple sclerosis
The authors analyze the course of 245 cased of multiple sclerosis. The mean annual frequency of attacks is 0.66 for all the patients (remittent forms and progressive forms). Although it is usually suggested th...
