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    Article

    Selective degradation of splicing factor CAPERα by anticancer sulfonamides

    A series of sulfonamides induced the ubiquitin-mediated degradation of the U2AF-related splicing factor, coactivator of activating protein-1 and estrogen receptor α (CAPERα), by promoting direct binding betwee...

    Taisuke Uehara, Yukinori Minoshima, Koji Sagane, Naoko Hata Sugi… in Nature Chemical Biology (2017)

  2. Article

    Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

    Epoxyquinol B (EPQB) is a fungal metabolite, containing two α,β-epoxy ketones. We previously showed that EPQB inhibited the signal transduction involved in angiogenesis through the binding to cysteine residues...

    Hiroshi Kamiyama, Takeo Usui, Masakazu Uramoto… in The Journal of Antibiotics (2008)

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