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  1. Article

    Open Access

    An autoimmune disease prevented by anti-retroviral drugs

    Both Aicardi-Goutières syndrome, a Mendelian mimic of congenital infection, and the autoimmune disease systemic lupus erythematosus can result from mutations in the gene encoding the enzyme Trex1. In mice, the...

    Gabriele B Beck-Engeser, Dan Eilat, Matthias Wabl in Retrovirology (2011)

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  2. Article

    Open Access

    Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer

    GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have imp...

    Amy M Lum, Bruce B Wang, Gabriele B Beck-Engeser, Lauri Li, Namitha Channa… in BMC Cancer (2010)

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  3. Article

    Open Access

    Pvt1-encoded microRNAs in oncogenesis

    The functional significance of the Pvt1 locus in the oncogenesis of Burkitt's lymphoma and plasmacytomas has remained a puzzle. In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loc...

    Gabriele B Beck-Engeser, Amy M Lum, Konrad Huppi, Natasha J Caplen… in Retrovirology (2008)

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  4. No Access

    Article

    Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

    Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin μ to γ2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and Cγ2b gene segments, and th...

    Peter D. Burrows, Gabriele B. Beck-Engeser, Matthias R. Wabl in Nature (1983)