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  1. Article

    Open Access

    Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells

    Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells ca...

    Amanda B Hummon, Jason J Pitt, Jordi Camps, Georg Emons, Susan B Skube… in Molecular Cancer (2012)

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  2. No Access

    Article

    Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA

    The identification of molecular features that contribute to the progression of breast cancer can provide valuable insight into the pathogenesis of this disease. Deregulated microRNA expression represents one t...

    Mark Mackiewicz, Konrad Huppi, Jason J. Pitt… in Breast Cancer Research and Treatment (2011)

  3. Article

    Open Access

    Pvt1-encoded microRNAs in oncogenesis

    The functional significance of the Pvt1 locus in the oncogenesis of Burkitt's lymphoma and plasmacytomas has remained a puzzle. In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loc...

    Gabriele B Beck-Engeser, Amy M Lum, Konrad Huppi, Natasha J Caplen… in Retrovirology (2008)

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  4. Article

    Open Access

    Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma

    North central China has some of the highest rates of esophageal squamous cell carcinoma in the world with cumulative mortality surpassing 20%. Mitochondrial DNA (mtDNA) accumulates more mutations than nuclear ...

    Christian C Abnet, Konrad Huppi, Ana Carrera, David Armistead, Keith McKenney… in BMC Cancer (2004)

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  5. No Access

    Article

    Double light chain producing lymphocytes

    The infrequent double light chain producing lymphocyte (DLCPL) is discussed in the context of allelic exclusion. Principally allelic selection rather than allelic exclusion would suggest a role for the DLCPL i...

    Lena Diaw, David Siwarski, Konrad Huppi in Immunologic Research (2001)

  6. No Access

    Article

    Mouse Chromosome 15

    Konrad Huppi, David Siwarski, Jennifer Kim, Verity Letts in Mammalian Genome (1999)

  7. No Access

    Article

    Mouse chromosome 15

    Konrad Huppi, David Siwarski, Verity Letts in Mammalian Genome (1998)

  8. No Access

    Article

    Mouse chromosome 15

    Konrad Huppi, David Siwarski in Mammalian Genome (1997)

  9. No Access

    Article

    Genomic instability in MycER-activated Rat1A-MycER cells

    The deregulated expression of c-Myc protein is associated with the non-random locus-specific amplification of the dihydrofolate reductase (DHFR) gene. This study was performed to determine whether additional chro...

    Sabine Mai, Monika Fluri, David Siwarski, Konrad Huppi in Chromosome Research (1996)

  10. No Access

    Article

    Mouse chromosome 4

    Robert Blank, Janan Eppig, Fred T. Fiedorek Jr., Wayne N. Frankel… in Mammalian Genome (1991)

  11. No Access

    Article

    Mouse chromosome 15

    Beverly Mock, Paul E. Neumann, Janan T. Eppig, Konrad Huppi in Mammalian Genome (1991)

  12. No Access

    Chapter

    Relative Predispositional Effect of a PADPRP Marker Allele in B-Cell and Some Non B-Cell Malignancies

    The gene PADPRP codes for a nuclear enzyme Poly (ADP-ribose) polymerase. This enzyme is a DNA binding protein that modulates chromatin structure adjacent to DNA strand breaks (Smulson and Sugimura 1980). The p...

    Kishor Bhatia, Konrad Huppi, Barry Cherney… in Mechanisms in B-Cell Neoplasia 1990 (1990)

  13. No Access

    Article

    Map** of the Ly-4 (L3T4) T-cell differentiation antigen on mouse chromosome 6 by the use of RFLPs in an interspecific cross

    Michael F. Seldin, Lawrence A. D'Hoostelaere, Konrad Huppi… in Immunogenetics (1988)

  14. No Access

    Article

    Myc-1 is centromeric to the linkage group Ly-6--Sis--Gdc-1 on mouse chromosome 15

    A survey of wild mouse DNA with a c-myc exon 1 probe revealed a Taq I restriction fragment length polymorphism (RFLP) among Mus species. As a result of this Taq I RFLP, a cross between Mus musculus domesticus and...

    Konrad Huppi, Robert Duncan, Michael Potter in Immunogenetics (1988)

  15. No Access

    Article

    The context of T-cell receptor gamma chain genes among wild mouse species

    We have examined the context of mouse T-cell receptor gamma (Tcr γ) chain variable (V γ) and constant (Cγ) genes among a panel of geographically isolated species of mice. Our Southern hybridization survey with Cγ...

    Konrad Huppi, Lawrence D'Hoostelaere, Michael Kiefer, Michael Steinmetz… in Immunogenetics (1986)

  16. No Access

    Article

    Localization of CTβ and C K on mouse chromosome 6

    In the mouse three lymphocyte gene families have been positioned on the proximal region of chromosome 6. Originally the immunoglobulin kappa light chain (Igk) and the thymocyte surface antigens Lyt-2 and Lyt-3...

    Lawrence A. D'Hoostelaere, Evelyne Jouvin-Marche, Konrad Huppi in Immunogenetics (1985)

  17. No Access

    Article

    Genetic polymorphism at the κ chain locus in mice: Comparisons of restriction enzyme hybridization fragments of variable and constant region genes

    Variable (Vκ) and constant (Cκ) region genes of the mouse kappa light chain have been compared in inbred strains and in geographically isolated or genetically separated populations of mice by Southern blot analys...

    Konrad Huppi, Evelyne Jouvin-Marche, Cynthia Scott, Michael Potter… in Immunogenetics (1985)

  18. No Access

    Article

    Amplification of immunoglobulin λ constant genes in populations of wild mice

    The λ immunoglobulin light chain (Igλ) locus of BALB/c inbred mice consists of two variable region gene segments (Vλ)1–3, and four constant region gene segments (Cλ)1,2,4,5. Each Cλ gene segment is associated wit...

    Cynthia L. Scott, J. Frederic Mushinski, Konrad Huppi, Martin Weigert… in Nature (1982)

  19. No Access

    Article

    Sequences at the somatic recombination sites of immunoglobulin light-chain genes

    The entire nucleotide sequence of a 1.7-kilobase embryonic DNA fragment containing five joining (J) DNA segments for mouse immunoglobulin κ chain gene has been determined. Each J DNA segment can encode amino a...

    Hitoshi Sakano, Konrad Hüppi, Günther Heinrich, Susumu Tonegawa in Nature (1979)

  20. No Access

    Article

    Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

    A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin γ1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing stu...

    Hitoshi Sakano, John H. Rogers, Konrad Hüppi, Christine Brack, André Traunecker… in Nature (1979)