-
Article
Case series: Adult testicular dermoid tumours – mature teratoma or pre-pubertal teratoma?
Adult testicular dermoid tumours are rare tumours with no reported potential for recurrent or metastatic spread. Despite this they are currently classified as mature teratoma and managed as if they have equiva...
-
Article
Open AccessA phase II trial of TIP (paclitaxel, ifosfamide and cisplatin) given as second-line (post-BEP) salvage chemotherapy for patients with metastatic germ cell cancer: a medical research council trial
This phase II trial describes the use of TIP chemotherapy (paclitaxel, ifosfamide and cisplatin) as salvage for patients with metastatic germ cell cancer (GCC) who have failed initial BEP (bleomycin, etoposide...
-
Article
Open AccessAdjuvant bleomycin, vincristine and cisplatin (BOP) for high-risk stage I non-seminomatous germ cell tumours: a prospective trial (MRC TE17)
Adjuvant BEP (bleomycin, etoposide, cisplatin) is effective treatment for high-risk clinical stage I (HRCS1) non-seminomatous germ cell tumours (NSGCT), but the known toxicities of etoposide, and the expansion...
-
Chapter and Conference Paper
A Randomised Trial of Two Radiotherapy Schedules in the Adjuvant Treatment of Stage I Seminoma (MRC TE18) — Preliminary Report
Adjuvant post-orchidectomy radiotherapy cures the majority of patients with stage I seminoma, but as approximately 80 per cent would remain relapse-free on surveillance alone, minimising radiotherapy — and hen...
-
Article
Open AccessA Medical Research Council randomized trial of single agent carboplatin versus etoposide and cisplatin for advanced metastatic seminoma
The UK Medical Research Council conducted this trial of carboplatin chemotherapy in advanced seminoma to compare single agent carboplatin with a standard combination of etoposide with cisplatin. The use of sin...
-
Article
Open AccessPrognostic factors in patients progressing after cisplatin-based chemotherapy for malignant non-seminomatous germ cell tumours
The aim of this study was to define prognostic parameters for survival in patients with malignant germ cell tumours progressing after platinum-based induction chemotherapy with or without surgery. A total of 1...
-
Chapter
Chylothorax in lymphoma: Mechanisms and management
Chylothorax is an uncommon and poorly described complication of non-Hodgkin’s lymphoma of any histological type or grade. Though patients usually have extensive lymphoma, supra-diaphragmatic disease is not alw...
-
Chapter
A complicated case of metastatic teratoma
Germ cell tumours of the testis are rare accounting for only 1% of all male malignancies, but have a special importance as they are by far the most common tumours in young men, their incidence is rapidly risin...
-
Article
Mechanisms in removal of tumor by antibody
We report two preliminary trials of antibody treatment of B-cell lymphoma. Advanced lymphoma was treated with chimeric FabFc2, in which mouse Fab'γ is linked to two human Fcγ1 fragments so as to recruit natural e...
-
Chapter and Conference Paper
Acute Leukaemia in the Elderly, Remission Induction Versus Palliative Therapy
Most patients with acute myeloid leukaemia (AML) are over 60 years old [1], remission rates are lower and survival poorer for this group in both AML [2] and for older patients with acute lymphocytic leukaemia ...
-
Article
Gynecologic cancer
-
Article
Gynecologic cancer
-
Article
Second look laparotomy in the management of epithelial cell carcinoma of the ovary
Case histories from 20 patients undergoing postchemotherapy "second look" laparotomy for metastatic epithelial cell carcinoma of the ovary were reviewed in an attempt to evaluate the usefulness of this procedu...