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  1. No Access

    Protocol

    Immunological Methods to Study Monoclonal Antibody Activity in Chronic Lymphocytic Leukaemia

    Over recent decades it has become increasingly apparent that malignant cells, including chronic lymphocytic leukemia (CLL) cells, do not exist in isolation. Rather they coalesce with numerous “normal” cells of...

    M. J. Carter, L. N. Dahal, K. L. S. Cleary… in Chronic Lymphocytic Leukemia (2019)

  2. Article

    Open Access

    Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells

    In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies ...

    M S Cragg, L Zhang, R R French, M J Glennie in British Journal of Cancer (1999)

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  3. No Access

    Article

    Mechanisms in removal of tumor by antibody

    We report two preliminary trials of antibody treatment of B-cell lymphoma. Advanced lymphoma was treated with chimeric FabFc2, in which mouse Fab'γ is linked to two human Fcγ1 fragments so as to recruit natural e...

    G. T. Stevenson, A. J. Bell, T. R. J. Evans, R. R. French, M. J. Glennie… in Cell Biophysics (1994)

  4. No Access

    Article

    High affinity GDP binding sites on brown adipose tissue mitochondria of genetically obese ‘fa/fa’ rats

    The number of high affinity [3H]GDP binding sites in brown adipose tissue mitochondria is normal in obese ( f a / f a ) rats in contrast to the reduced number of low affinity GDP binding sites. Adrenalectomy corr...

    R. R. French, S. J. Holt, D. A. York in Bioscience Reports (1985)

  5. No Access

    Article

    Arrhenius plot characteristics of adipocyte-plasma-membrane adenylate cyclase activity in lean and genetically obese (ob/ob) mice

    Arrhenius plots of fluoride- and guanine-nucleotide-stimulated adenylate cyclase activity were linear in adipocyte plasma membranes from lean and obese (ob/ob) mice . Arrhenius plots of isoprenaline-stimulated...

    R. R. French, D. A. York in Bioscience Reports (1984)

  6. Article

    The regulation of adenylate cyclase in adipocyte plasma membrane from genetically obese (ob/ob) mice

    Adenylate cyclase activity was determined using a purified plasma membrane fraction prepared from isolated adipocytes by a Percoll gradient centrifugation procedure. The activation of adenylate cyclase by isop...

    R. R. French, D. A. York in Diabetologia (1984)

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