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Article
Open AccessPhase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001)
Penis cancer is rare and clinical trial evidence on which to base treatment decisions is limited. Case reports suggest that the combination of docetaxel, cisplatin and 5-flurouracil (TPF) is highly active in t...
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Article
Open AccessAdjuvant bleomycin, vincristine and cisplatin (BOP) for high-risk stage I non-seminomatous germ cell tumours: a prospective trial (MRC TE17)
Adjuvant BEP (bleomycin, etoposide, cisplatin) is effective treatment for high-risk clinical stage I (HRCS1) non-seminomatous germ cell tumours (NSGCT), but the known toxicities of etoposide, and the expansion...
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Article
Open AccessEpirubicin carboplatin and 5-fluorouracil (ECarboF) chemotherapy in metastatic hormone refractory prostate cancer
The aim of this study was to examine the efficacy and toxicity of the epirubicin, carboplatin and 5-fluorouracil (ECarboF) regime in patients aged 70 or less with metastatic prostate cancer resistant to LHRH a...
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Article
Open AccessPaclitaxel-containing high-dose chemotherapy for relapsed or refractory testicular germ cell tumours
High-dose regimes containing etoposide, carboplatin and an oxazaphospharine can salvage 30–40% of patients with relapsed or refractory male germ cell tumours (GCTs). The additional benefit of paclitaxel in suc...
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Article
The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer
Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory p...
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Article
Open AccessCisplatin neurotoxicity in the treatment of metastatic germ cell tumour: time course and prognosis
In order to ascertain the incidence and prognosis of cisplatin-induced neurotoxicity in testis cancer patients undergoing combination chemotherapy, 29 patients with metastatic disease were studied prospectivel...
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Article
Open AccessA Medical Research Council randomized trial of single agent carboplatin versus etoposide and cisplatin for advanced metastatic seminoma
The UK Medical Research Council conducted this trial of carboplatin chemotherapy in advanced seminoma to compare single agent carboplatin with a standard combination of etoposide with cisplatin. The use of sin...
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Chapter
The management of bladder cancer — a case history
Bladder cancer is a common disease, accounting worldwide for approximately 3.5% of all new cancers. It manifests a wide spectrum of disease, ranging from a solitary, papillary, non-invasive lesion, through to ...
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Article
Pharmacokinetics ofcis-dichloro-trans-dihydroxy-bis-isopropylamine platinum IV (iproplatinum, chip) in patients with normal and impaired renal function and following intraperitoneal administration
CHIP is a quadrivalent platinum (Pt) complex, introduced clinically as a less toxic alternative tocis-platinum. The drug’s major route of excretion is via the kidneys, and in this study the pharmacokinetics of un...
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Article
The treatment of postmenopausal women with advanced breast cancer with buserelin
Repeated administration of long-acting analogues of gonadotrophin-releasing hormone down-regulates the pituitary gonadotrophins and gonadal hormones. The activity of these compounds in premenopausal women with...
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Article
High-dose cyclophosphamide with autologous bone marrow rescue after conventional chemotherapy in the treatment of small cell lung carcinoma
Whithin an original consecutive series of 94 patients, 36 eligible patients with small cell lung carcinoma were treated with high-dose cyclophosphamide 7 g/m2 after conventional chemotherapy with VP16, adriamycin...
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Article
Hydralazine-induced lupus: is there a toxic metabolic pathway?
The metabolism of hydralazine in a group of slow acetylator patients [6] with the drug-induced lupus syndrome was compared with the metabolism in asymptomatic control subjects [17]. There were no toxicological...
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Chapter
The Development of Resistance to Methotrexate in a Human Leukaemia (AML) Growing in Nude Mice
The line was derived by s. c. implantation of 2.4 x 106 leukaemic cells. The resultant solid tumour was shown to be sensitive to methotrexate at its third passage. Development of the resistant line commenced at p...
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Chapter
JM8 Development and Clinical Projects
Since its introduction in the early 1970’s cisplatin has become established as one of the major cytotoxic drugs used in the treatment of cancer. Of particular note are its application in combination therapy to...
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Article
Early clinical studies with cis-diammine-1,1-cyclobutane dicarboxylate platinum II
cis-Diammine-1,1-cyclobutane dicarboxylate platinum II (CBDCA, JM8), an analogue of cisplatin showing reduced toxicity in preclinical studies, was evaluated in 60 patients. Doses were given initially every 3 w...
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Article
Polymorphically acetylated aminoglutethimide in humans
The urinary excretion during 24 h of aminoglutethimide (AG) its major metabolite (N-acetylAG) and two minor metabolites (N-formylAG and nitroG) were measured in 10 volunteers given AG who had been typed for ac...
