-
Article
Open AccessSecond cancer risk and mortality in men treated with radiotherapy for stage I seminoma
Patients with stage I testicular seminoma are typically diagnosed at a young age and treatment is associated with low relapse and mortality rates. The long-term risks of adjuvant radiotherapy in this patient g...
-
Article
Open AccessProstate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis
The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRC...
-
Chapter and Conference Paper
Assessing Correlations between the Spatial Distribution of Dose to the Rectal Wall and Late Rectal Toxicity after Prostate Radiotherapy
Many studies have been performed to assess correlations between measures derived from dose-volume histograms and late rectal toxicities for radiotherapy of prostate cancer. The purpose of this study was to ass...
-
Article
Open AccessEvidence-based pragmatic guidelines for the follow-up of testicular cancer: optimising the detection of relapse
Testicular germ cell tumours (TGCTs) are the most common cause of cancer in men between the ages of 15 and 40 years, and, overall, the majority of patients should expect to be cured. The European Germ Cell Can...
-
Article
A phase 2 study of high-activity 186Re-HEDP with autologous peripheral blood stem cell transplant in progressive hormone-refractory prostate cancer metastatic to bone
We investigated the potential for improvement in disease control by use of autologous peripheral blood stem cell transplant (PBSCT) to permit administration of high activities of 186Re-hydroxyethylidene diphospho...
-
Chapter
Intensity Modulated Radiotherapy in Cancer of the Larynx
-
Article
Open AccessFertility, gonadal and sexual function in survivors of testicular cancer
Modern treatments cure most testicular cancer patients, so an important goal is to minimise toxicity. Fertility and sexual functioning are key issues for patients. We have evaluated these outcomes in a cross-s...
-
Article
Open AccessAdjuvant bleomycin, vincristine and cisplatin (BOP) for high-risk stage I non-seminomatous germ cell tumours: a prospective trial (MRC TE17)
Adjuvant BEP (bleomycin, etoposide, cisplatin) is effective treatment for high-risk clinical stage I (HRCS1) non-seminomatous germ cell tumours (NSGCT), but the known toxicities of etoposide, and the expansion...
-
Article
Open AccessA modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy
After radiotherapy for pelvic cancer, chronic gastrointestinal problems may affect quality of life (QOL) in 6–78% of patients. This variation may be due to true differences in outcome in different diseases, an...
-
Article
Open AccessPhase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects
Radical radiotherapy is a standard form of management of localised prostate cancer. Conformal treatment planning spares adjacent normal tissues reducing treatment-related side effects and may permit safe dose ...
-
Article
Open AccessHPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease
The candidate prostate cancer susceptibility gene HPC2/ELAC2 has two common coding polymorphisms: (Ser→Leu 217) and (Ala→Thr 541). The Thr541 variant in the HPC2/ELAC2 gene has previously been reported to be at a...
-
Article
Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer
Epidemiological studies have suggested an association between low selenium levels and the development of prostate cancer. Human cellular glutathione peroxidase I (hGPX1) is a selenium-dependent enzyme that pro...
-
Article
Open AccessHigh activity Rhenium-186 HEDP with autologous peripheral blood stem cell rescue: a phase I study in progressive hormone refractory prostate cancer metastatic to bone
We tested the feasibility and toxicity of high activities Rhenium-186 hydroxyethylidene diphosphonate, with peripheral blood stem cell rescue in patients with progressive hormone refractory prostate cancer met...
-
Article
Open AccessPre-treatment nomogram for biochemical control after neoadjuvant androgen deprivation and radical radiotherapy for clinically localised prostate cancer
Phase III studies have demonstrated the clinical benefit of adding neo-adjuvant androgen deprivation to radical radiotherapy for clinically localised prostate cancer. We have developed a nomogram to describe t...
-
Chapter and Conference Paper
Multivariate Analysis of Predictive Factors of Late Relapse in 1264 Patients with Testicular Germ Cell Tumours
10–30 per cent of patients with testicular germ cell tumours (GCTs) relapse after initial treatment. Most of these relapses happen in the first two years after treatment.
-
Chapter and Conference Paper
Factors Associated with Bleomycin Lung Toxicity in Germ Cell Tumour Patients Treated at the Royal Marsden Hospital Between 1982 and 1999
Bleomycin is a polypeptide antibiotic, anti-neoplastic agent, which has been used in the treatment of germ cell tumours for over 20 years. Pulmonary toxicity has been known since the early clinical trials in t...
-
Article
Open AccessA Medical Research Council randomized trial of single agent carboplatin versus etoposide and cisplatin for advanced metastatic seminoma
The UK Medical Research Council conducted this trial of carboplatin chemotherapy in advanced seminoma to compare single agent carboplatin with a standard combination of etoposide with cisplatin. The use of sin...
-
Article
Open AccessThe utility of tumour markers in assessing the response to chemotherapy in advanced bladder cancer
In patients with advanced bladder cancer receiving chemotherapy, early assessment of response can avoid unnecessary toxicity. The aim of this study was to assess the role of tumour markers in monitoring respon...
-
Article
Evaluation of a rosetting method in detection of breast cancer cells
-
Article
Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen
We have developed a technique for the immunocytochemical staining of marrow smears using antiserum to epithelial membrane antigen (EMA). This membrane component is confined to, but widely distributed in, epith...
