14 Result(s)
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E. R. Maher
Oncology
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Article
Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt–Hogg–Dubé tumour suppressor gene (FLCN)
Birt–Hogg–Dubé (BHD) syndrome, is a dominantly inherited familial cancer syndrome associated with susceptibility to renal cell carcinoma (RCC) caused by inactivating mutations in the folliculin (FLCN) gene. The p...
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Article
Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma
The detection of promoter region hypermethylation and transcriptional silencing has facilitated the identification of candidate renal cell carcinoma (RCC) tumour suppressor genes (TSGs). We have used a genome-...
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Article
Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis
We have recently described the N-terminal RAS association domain family of genes, RASSF7–10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5′-CpG island...
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Article
The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways
The Ras-assocation domain family (RASSF) of tumor suppressor proteins until recently contained six proteins named RASSF1–6. Recently, four novel family members, RASSF7–10, have been identified by homology searche...
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Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma
Promoter region hyermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many types of human cancers. Functional epigenetic studies, in which gene expre...
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Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer
RASSF2 is a recently identified member of a class of novel tumour suppressor genes, all containing a ras-association domain. RASSF2 resides at 20p13, a region frequently lost in human cancers. In this report w...
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Open AccessFunctional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma
Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivat...
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Article
Identification of novel VHL targets that are associated with the development of renal cell carcinoma
von Hippel–Lindau (VHL) disease is a dominantly inherited family cancer syndrome characterized by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma (RCC) and phaeoc...
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Open AccessEpigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour
Epigenetic alterations in the 11p15.5 imprinted gene cluster are frequent in human cancers and are associated with disordered imprinting of insulin-like growth factor (IGF)2 and H19. Recently, an imprinted gene c...
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Article
Open AccessEpigenetic inactivation of SLIT3 and SLIT1 genes in human cancers
In Drosophila, the Slit gene product, a secreted glycoprotein, acts as a midline repellent to guide axonal development during embryogenesis. Three human Slit gene orthologues have been characterised and recent...
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Article
Open AccessInvestigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma
Germline mutations in the succinate dehydrogenase (SDH) (mitochondrial respiratory chain complex II) subunit B gene, SDHB, cause susceptibility to head and neck paraganglioma and phaeochromocytoma. Previously, we...
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Article
Open AccessSLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma
The 3p21.3 RASSF1A tumour suppressor gene (TSG) provides a paradigm for TSGs inactivated by promoter methylation rather than somatic mutations. Recently, we identified frequent promoter methylation without somati...
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Analysis of the TSC1and TSC2genes in sporadic renal cell carcinomas
The genetic events involved in the aetiology of non-clear-cell renal cell carcinoma (RCC) and a proportion of clear cell RCC remain to be defined. Germline mutations of the TSC1and TSC2genes cause tuberous sclero...
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Molecular Genetics of Wilms’ Tumour and Renal Cell Carcinoma
It is now generally accepted that cancer is caused by an accumulation of genetic mutations. However, only a small proportion of cancer-associated gene mutations are inherited (i.e. are germline mutations); the...
