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  1. Article

    Open Access

    Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation

    Altered mitochondrial function and large-scale changes to DNA methylation patterns in the nuclear genome are both hallmarks of colorectal cancer (CRC). Mitochondria have multiple copies of a 16 kb circular gen...

    M. J. Morris, L. B. Hesson, R. C. Poulos, R. L. Ward, J. W. H. Wong… in Biomarker Research (2018)

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  2. Article

    Open Access

    AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo

    The cytidine analogue, 5-azacytidine (AZA; 5-AZA-cR), is the primary treatment for myelodysplastic syndrome and chronic myelomonocytic leukaemia. However, only ~50% of treated patients will respond to AZA and ...

    A Unnikrishnan, A N Q Vo, R Pickford, M J Raftery, A C Nunez, A Verma… in Leukemia (2018)

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  3. No Access

    Article

    RASSF2 associates with and stabilizes the proapoptotic kinase MST2

    RASSF2 is a tumour suppressor that in common with the rest of the RASSF family contains Ras association and SARAH domains. We identified the proapoptotic kinases, MST1 and MST2, as the most significant binding...

    W N Cooper, L B Hesson, D Matallanas, A Dallol, A von Kriegsheim, R Ward… in Oncogene (2009)

  4. No Access

    Article

    Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer

    RASSF2 is a recently identified member of a class of novel tumour suppressor genes, all containing a ras-association domain. RASSF2 resides at 20p13, a region frequently lost in human cancers. In this report w...

    W N Cooper, R E Dickinson, A Dallol, E V Grigorieva, T V Pavlova, L B Hesson… in Oncogene (2008)

  5. No Access

    Article

    Evaluation of the 3p21.3 tumour-suppressor gene cluster

    Deletions of the 3p21.3 region are a frequent and early event in the formation of lung, breast, kidney and other cancers. Intense investigation of allelic losses and the discovery of overlap** homozygous del...

    L B Hesson, W N Cooper, F Latif in Oncogene (2007)