23 Result(s)

Article

Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma

The detection of promoter region hypermethylation and transcriptional silencing has facilitated the identification of candidate renal cell carcinoma (RCC) tumour suppressor genes (TSGs). We have used a genome-...

M R Morris, C J Ricketts, D Gentle, F McRonald, N Carli, H Khalili, M Brown… in Oncogene (2011)

Article

Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma

Promoter region hyermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many types of human cancers. Functional epigenetic studies, in which gene expre...

M R Morris, C Ricketts, D Gentle, M Abdulrahman, N Clarke, M Brown, T Kishida… in Oncogene (2010)

Article

Interfacial instability in bilayer films due to solvent evaporation

We perform a linear analysis of the Marangoni instability of a deformable interface between two fluid layers of finite depths, submitted to a gradient of solvent concentration induced by evaporation at the top...

M. Souche, N. Clarke in The European Physical Journal E (2009)

Article

Instabilities in thin-film binary mixtures

Binary mixtures of ultra-thin films are subject to both height and concentration fluctuations, either of which, under the appropriate conditions, can become unstable. We investigate a simple general thermodyna...

N. Clarke in The European Physical Journal E (2004)

Article

Modelling the production and transport of dissolved organic carbon in forest soils

DyDOC describes soil carbon dynamics, with a focus on dissolved organic carbon (DOC). The model treats the soil as a three-horizon profile, and simulates metabolic carbon transformations, sorption reactions an...

B. Michalzik, E. Tip**, J. Mulder, J.F. Gallardo Lancho, E. Matzner… in Biogeochemistry (2003)

Article

Early stages of phase separation from polydisperse polymer mixtures

We study the early stages of phase separation in a mixture of a polydisperse and a monodisperse polymer within the Cahn-Hilliard framework. We model the polydisperse component using a finite, but arbitrarily l...

N. Clarke in The European Physical Journal E (2001)

Article

Studies of aluminium complexation to humic and fulvic acids using a method for the determination of quickly reacting aluminium

We have recently presented a method for the determination of quickly reacting aluminium in natural waters based on kinetic discrimination in a flow system. This method has been further validated using both an ...

N. Clarke, L. -G. Danielsson, A. Sparén in Water, Air, and Soil Pollution (1995)

Chapter and Conference Paper

Identification of Stress Tolerance Traits in Sugar Beet

Drought stress is probably the largest single cause of lost potential yield in UK sugar beet production and global warming seems certain to exacerbate this effect. Irrigation, the obvious corrective measure fo...

N. Clarke, H. Hetschkun, C. Jones… in Interacting Stresses on Plants in a Changi… (1993)

Chapter and Conference Paper

A Convenient Entropy Satisfying T.V.D. Scheme for Computational Aerodynamics

Conservative shock capturing methods for the unsteady Euler equations are reviewed and it is shown that the concepts of entropy satisfaction and total variation diminution can be applied to the classical Lax-W...

N. Clarke, R. Saunders, D. M. Causon in Proceedings of the Eighth GAMM-Conference … (1990)

Chapter and Conference Paper

Convenient entropy-satisfying T.V.D. schemes with applications

N. Clarke, D. M. Ingram, D. M. Causon… in Twelfth International Conference on Numeri… (1990)

Article

Preliminary observations on the technique of monitoring platelet aggregation in whole blood using a rotor system

PLATELET aggregation is now recognised as an important early event in thrombosis. Problems associated with the measurement of the degree of platelet aggregation in plasma are outlined.

N. Clarke, V. McCabe, B. P. Woods, A. Dennehy… in Irish Journal of Medical Science (1975)

Article

Details of a rotor system for investigating platelet aggregation in whole blood

Working details of the prototype apparatus, for producing and monitoring platelet aggregation in whole blood, are described. The blood is subjected first to varying degrees of turbulence or agitation by the di...

T. Moriarty, V. McCabe, N. Clarke in Irish Journal of Medical Science (1975)

Article

A water-bath for multiple visual screening of platelet aggregation in stirred plasma

A transparent and illuminated water bath is described which permits rapid preliminary tests of the effect of inducing or inhibiting drugs on platelet aggregation in plasma. The plasma is agitated by a sealed m...

N. Clarke, L. Duffy in Irish Journal of Medical Science (1974)

Article

Book reviews

Michael Solomons, Myra Kelly, A. Forbes Brown… in Irish Journal of Medical Science (1973)

Article

Haemolysis during haemostasis in skin puncture

Plasma haemoglobin levels have been measured using a micro-technique in blood collected from skin stab wounds and by venepuncture from 25 human subjects. It was found that there was significantly greater haemo...

D. McCarthy, N. Clarke in Irish Journal of Medical Science (1973)