Skip to main content

3 Result(s)

within F E Lock Remove this filter

and

  1. No Access

    Article

    Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

    The sub-population of tumor cells termed ‘cancer stem cells’ (CSCs) possess the capability to generate tumors, undergo epithelial–mesenchymal transition (EMT) and are implicated in metastasis, making treatment...

    F E Lock, P C McDonald, Y Lou, I Serrano, S C Chafe, C Ostlund, S Aparicio… in Oncogene (2013)

  2. No Access

    Article

    Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial–mesenchymal transition (EMT)

    Epithelial-to-mesenchymal transition (EMT) causes fibrosis, cancer progression and metastasis. Integrin-linked kinase (ILK) is a focal adhesion adaptor and a serine/threonine protein kinase that regulates cell...

    I Serrano, P C McDonald, F E Lock, S Dedhar in Oncogene (2013)

  3. No Access

    Article

    The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

    The Ras-assocation domain family (RASSF) of tumor suppressor proteins until recently contained six proteins named RASSF1–6. Recently, four novel family members, RASSF7–10, have been identified by homology searche...

    F E Lock, N Underhill-Day, T Dunwell, D Matallanas, W Cooper, L Hesson… in Oncogene (2010)