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Article
Open AccessPyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients are at a high risk of develo** metastases in the brain. However, research focusing on treatment strategies for hormonal r...
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Article
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
Accumulating studies have shown that tumors are regulated by nerves, and there is abundant nerve infiltration in the tumor microenvironment. Many solid tumors including breast cancer (BRCA) have different degr...
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Article
"In the spectrum of people who are healthy": Views of individuals at risk of dementia on using neurotechnology for cognitive enhancement
Neurotechnological cognitive enhancement has become an area of intense scientific, policy, and ethical interest. However, while work has increasingly focused on ethical views of the general public, less studie...
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Article
Open AccessNoncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
Whole-genome sequencing of longitudinal tumor pairs representing transformation of follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements (double-hit lymphoma) identified coding and no...
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Article
Open AccessComparison of central venous catheter thoracic drainage and traditional closed thoracic drainage following minimally invasive surgery for esophageal carcinoma: a retrospective analysis
To compare the effectiveness and safety of central venous catheter thoracic drainage (CVCTD) with traditional closed thoracic drainage (TCTD) after minimally invasive surgery for esophageal cancer.
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Article
Systemic immune-inflammation index and the survival of hepatocellular carcinoma patients after transarterial chemoembolization: a meta-analysis
The systemic immune-inflammation index (SII), derived from neutrophil, platelet, and lymphocyte counts, has been associated with prognosis of patients with cancer. We performed a meta-analysis to evaluate the ...
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Article
Identifying Circulating Tumor DNA Mutations Associated with Neoadjuvant Chemotherapy Efficacy in Local Advanced Breast Cancer
Circulating tumor DNA (ctDNA) correlates with tumor burden and provides early detection of treatment response and tumor genetic alterations in breast cancer. Neoadjuvant chemotherapy (NACT) has become standard...
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Article
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy
The hippocampus is the most common seizure focus in people. In the hippocampus, aberrant neurogenesis plays a critical role in the initiation and progression of epilepsy in rodent models, but it is unknown whe...
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Reference Work Entry In depth
Hippocampal Memory Prosthesis
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Reference Work Entry In depth
Memory Decoding Model
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Article
Open AccessHigher efficacy and reduced adverse reactions in neoadjuvant chemotherapy for breast cancer by using pegylated liposomal doxorubicin compared with pirarubicin
The present study aimed to investigate the efficacy and toxicity of pegylated liposomal doxorubicin (PLD) in preoperative neoadjuvant chemotherapy for patients with breast cancer by comparing with conventional...
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Living Reference Work Entry In depth
Memory Decoding Model
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Living Reference Work Entry In depth
Hippocampal Memory Prosthesis
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Chapter
Neurostimulator for Hippocampal Memory Prosthesis
In this chapter, we discuss the design, fabrication, and evaluation of a neurostimulator for generating neural code–based electrical stimulation pulses. We show that, through multiplexing, this system can deli...
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Article
Open AccessA miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer
Reprogrammed energy metabolism, especially the Warburg effect (aerobic glycolysis), is an emerging hallmark of cancer. Different from other breast cancer subtypes, triple-negative breast cancer (TNBC) exhibits...
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Article
CELLO: a longitudinal data analysis toolbox untangling cancer evolution
The complex pattern of cancer evolution poses a huge challenge to precision oncology. Longitudinal sequencing of tumor samples allows us to monitor the dynamics of mutations that occurred during this clonal ev...
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Article
Open AccessCharacterization of a recombinant thermotolerant argonaute protein as an endonuclease by broad guide utilization
Prokaryotic argonaute proteins (pAgos) play an important role in host defense in vivo. Most importantly, the thermophilic pAgos with endonuclease activity hold great potential for programmable genetic manipula...
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Article
Open AccessNogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells
Tamoxifen is typically used to treat patients with estrogen receptor alpha (ERα)-positive breast cancer. However, 30% of these patients gain acquired resistance to tamoxifen during or after tamoxifen treatment...
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Chapter
Spatiotemporal Patterns of Granule Cell Activity Revealed by a Large-Scale, Biologically Realistic Model of the Hippocampal Dentate Gyrus
Interest in the hippocampus has generated vast amounts of experimental data describing hippocampal properties, including anatomical, morphological, biophysical, and synaptic transmission levels of analysis. Ho...
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Chapter
Characterization of Complex Brain Functions with Sparse Nonlinear Dynamical Modeling
Building computational models to explain and mimic complex brain functions is one of the most challenging goals in science and engineering. In this article, we describe a specific form of input-output model of...
