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Open AccessArgonaute with stepwise endonuclease activity promotes specific and multiplex nucleic acid detection
Argonaute proteins (Agos) from thermophiles function as endonucleases via guide-target base-pairing cleavage for host defense. Since guides play a key role in regulating the catalytic specificity of Agos, eluc...
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Open AccessCharacterization of a recombinant thermotolerant argonaute protein as an endonuclease by broad guide utilization
Prokaryotic argonaute proteins (pAgos) play an important role in host defense in vivo. Most importantly, the thermophilic pAgos with endonuclease activity hold great potential for programmable genetic manipula...
