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  1. No Access

    Article

    Egr1 regulates regenerative senescence and cardiac repair

    Senescence plays a key role in various physiological and pathological processes. We reported that injury-induced transient senescence correlates with heart regeneration, yet the multi-omics profile and molecul...

    Lingling Zhang, Jacob Elkahal, Tianzhen Wang… in Nature Cardiovascular Research (2024)

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    Article

    Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

    Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of redifferentiation remains largely unexplored. Redifferentiatio...

    Avraham Shakked, Zachary Petrover, Alla Aharonov… in Nature Cardiovascular Research (2023)

  3. No Access

    Article

    ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

    Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are key mediators of heart regeneration,...

    Alla Aharonov, Avraham Shakked, Kfir Baruch Umansky, Alon Savidor… in Nature Cell Biology (2020)

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    Article

    The extracellular matrix protein agrin promotes heart regeneration in mice

    The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in t...

    Elad Bassat, Yara Eid Mutlak, Alex Genzelinakh, Ilya Y. Shadrin… in Nature (2017)

  5. No Access

    Article

    ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

    The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation, although this capacity markedly diminishes after the first week of life. Neuregulin-1 (NRG1) administration has b...

    Gabriele D’Uva, Alla Aharonov, Mattia Lauriola, David Kain… in Nature Cell Biology (2015)