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  1. No Access

    Article

    Egr1 regulates regenerative senescence and cardiac repair

    Senescence plays a key role in various physiological and pathological processes. We reported that injury-induced transient senescence correlates with heart regeneration, yet the multi-omics profile and molecul...

    Lingling Zhang, Jacob Elkahal, Tianzhen Wang… in Nature Cardiovascular Research (2024)

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    Protocol

    Myocardial Infarction Techniques in Adult Mice

    The discovery of endogenous regenerative potential of the heart in zebrafish and neonatal mice has shifted the cardiac regenerative field towards the utilization of intrinsic regenerative mechanisms in the mam...

    Elad Bassat, Dahlia E. Perez, Eldad Tzahor in Cardiac Regeneration (2021)

  3. No Access

    Article

    The extracellular matrix protein agrin promotes heart regeneration in mice

    The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in t...

    Elad Bassat, Yara Eid Mutlak, Alex Genzelinakh, Ilya Y. Shadrin… in Nature (2017)

  4. No Access

    Article

    ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

    The murine neonatal heart can regenerate after injury through cardiomyocyte (CM) proliferation, although this capacity markedly diminishes after the first week of life. Neuregulin-1 (NRG1) administration has b...

    Gabriele D’Uva, Alla Aharonov, Mattia Lauriola, David Kain… in Nature Cell Biology (2015)