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Article
Open AccessCardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human ...
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Article
The extracellular matrix protein agrin promotes heart regeneration in mice
The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in t...
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Article
Open AccessRapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells
Cardiac cell therapies involving bone marrow-derived human mesenchymal stem cells (hMSCs) have shown promising results, although their mechanisms of action are still poorly understood. Here, we investigated di...
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Article
In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons
Dieterich et al. describe a methodology to label all newly synthesized neuronal proteins in situ. This method, which they name FUNCAT, relies on the inclusion of noncanonical amino acids and selective fluorescent...
