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  1. Article

    Open Access

    Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients

    The non-canonical translation initiation factor EIF4G2 plays essential roles in cellular stress responses via translation of selective mRNA cohorts. Currently there is limited and conflicting information regar...

    Sara Meril, Maya Muhlbauer Avni, Chen Lior, Marcela Bahlsen, Tsviya Olender… in Oncogene (2024)

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  2. No Access

    Article

    Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

    Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of redifferentiation remains largely unexplored. Redifferentiatio...

    Avraham Shakked, Zachary Petrover, Alla Aharonov… in Nature Cardiovascular Research (2023)

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    Article

    Spatial discordances between mRNAs and proteins in the intestinal epithelium

    The use of transcriptomes as reliable proxies for cellular proteomes is controversial. In the small intestine, enterocytes operate for 4 days as they migrate along villi, which are highly graded microenvironme...

    Yotam Harnik, Lisa Buchauer, Shani Ben-Moshe, Inna Averbukh… in Nature Metabolism (2021)

  4. No Access

    Article

    ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

    Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are key mediators of heart regeneration,...

    Alla Aharonov, Avraham Shakked, Kfir Baruch Umansky, Alon Savidor… in Nature Cell Biology (2020)

  5. Article

    Open Access

    The genetic basis for the adaptation of E. coli to sugar synthesis from CO2

    Understanding the evolution of a new metabolic capability in full mechanistic detail is challenging, as causative mutations may be masked by non-essential "hitchhiking" mutations accumulated during the evoluti...

    Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi… in Nature Communications (2017)

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    Article

    Communication between viruses guides lysis–lysogeny decisions

    Temperate viruses can become dormant in their host cells, a process called lysogeny. In every infection, such viruses decide between the lytic and the lysogenic cycles, that is, whether to replicate and lyse t...

    Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron… in Nature (2017)

  7. No Access

    Protocol

    Quantification of Proteins by Label-Free LC-MSE

    Quantitative proteomics by LC-MS/MS is a widely used approach for quantifying a significant portion of any complex proteome. Among the different techniques used for this purpose, one is by use of Data Independ...

    Alon Savidor, Yishai Levin in Shotgun Proteomics (2014)

  8. Article

    Open Access

    Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

    The genome of Phytophthora infestans, the pathogen that triggered the Irish potato famine in the nineteenth century, has been sequenced. It remains a devastating pathogen, with late blight destroying crops worth ...

    Brian J. Haas, Sophien Kamoun, Michael C. Zody, Rays H. Y. Jiang… in Nature (2009)

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