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  1. No Access

    Article

    Egr1 regulates regenerative senescence and cardiac repair

    Senescence plays a key role in various physiological and pathological processes. We reported that injury-induced transient senescence correlates with heart regeneration, yet the multi-omics profile and molecul...

    Lingling Zhang, Jacob Elkahal, Tianzhen Wang… in Nature Cardiovascular Research (2024)

  2. No Access

    Article

    Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

    Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of redifferentiation remains largely unexplored. Redifferentiatio...

    Avraham Shakked, Zachary Petrover, Alla Aharonov… in Nature Cardiovascular Research (2023)

  3. Article

    Open Access

    Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

    Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypi...

    Nathaniel Kastan, Ksenia Gnedeva, Theresa Alisch… in Nature Communications (2021)

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    Article

    ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration

    Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are key mediators of heart regeneration,...

    Alla Aharonov, Avraham Shakked, Kfir Baruch Umansky, Alon Savidor… in Nature Cell Biology (2020)