21 Result(s)

Article

Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities

Prior conclusions that autologous neonatal red blood cells (RBC) have substantially shorter lifespans than allogeneic adult RBCs were not based on direct comparison of autologous neonatal vs. allogeneic adult ...

Denison J. Kuruvilla, John A Widness, Demet Nalbant, Robert L Schmidt… in Pediatric Research (2017)

Article

A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis

Postnatal hemoglobin (Hb) production in anemic preterm infants is determined by several factors including the endogenous erythropoietin levels, allogeneic RBC transfusions administered to treat anemia, and dev...

Denison J. Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt… in The AAPS Journal (2016)

Article

A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

Fetal RBCs are produced during a period of very rapid growth and stimulated erythropoiesis under hypoxic intrauterine conditions. Fetal RBC life span varies with gestational age (GA) and is shorter than that i...

Denison J. Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt… in The AAPS Journal (2015)

Article

Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen–mismatched RBCs

Anemia, a common condition among critically ill premature infants, is affected by red blood cell (RBC) survival (RCS). We hypothesized that transfused allogeneic Kidd antigen–mismatched RBCs would demonstrate ...

John A. Widness, Demet Nalbant, Nell I. Matthews, Ronald G. Strauss… in Pediatric Research (2013)

Article

Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion

Study of the pathophysiology and treatment of anemia of prematurity is facilitated by direct measurement of red cell volume (RCV) utilizing microliter quantities of blood samples. Our objective was to compare ...

Demet Nalbant, Prasad Bhandary, Nell I. Matthews, Robert L. Schmidt… in Pediatric Research (2013)

Article

Red Cell Volume Can Be Accurately Determined in Sheep Using a Nonradioactive Biotin Label

The sheep has served as an informative animal model for investigation of human fetal and newborn erythropoiesis and red blood cell (RBC) kinetics. We previously validated the permanent label (¹⁴C)cyanate for meas...

Donald M Mock, Nell I Mock, Gary L Lankford, Leon F Burmeister… in Pediatric Research (2008)

Article

Hematocrit Correlates Well with Circulating Red Blood Cell Volume in Very Low Birth Weight Infants

Although circulating red blood cell (RBC) volume is a better measure of total body oxygen delivering capacity than hematocrit (HCT), circulating RBC volume is more difficult to measure. Thus, the HCT is often ...

Donald M Mock, Edward F Bell, Gary L Lankford, John A Widness in Pediatric Research (2001)

Article

Hematocrit Correlates Well with Red Cell Volume in Preterm Infants 784

Donald M Mock, Gary L Lankford, John A Widness, Edward F Bell in Pediatric Research (1998)

Article

Circulating Red Cell Volume and Red Cell Survival Can Be Accurately Determined in Sheep Using the [¹⁴C]Cyanate Label

The sheep commonly serves as an animal model for investigation of human fetal and newborn erythropoiesis and red blood cell kinetics. Measurement of red cell volume (RCV) and survival (RCS) in sheep would be u...

Donald M Mock, Gary L Lankford, Leon F Burmeister, Ronald G Strauss in Pediatric Research (1997)

Article

[¹⁴C]Cyanate Labeling of Sheep Red Cells: Covalent Binding to Hemoglobin Continues in Vivo for a Day

The sheep is a useful model to study fetal and newborn physiology including perinatal erythropoiesis and red cell kinetics. A practical, economical method for measuring red cell survival (RCS) in sheep would b...

Donald M Mock, Ronald G Strauss, Gary L Lankford in Pediatric Research (1997)

Article

Effects of Biotin Deficiency on Plasma and Tissue Fatty Acid Composition: Evidence for Abnormalities in Rats

ABSTRACT: Abnormalities of fatty acid composition have been detected in the plasma of patients who developed frank biotin deficiency during parenteral nutrition. We sought to determine which abnormalities of f...

Donald M Mock, Nell I Mock, Susan B Johnson, Ralph T Holman in Pediatric Research (1988)

Article

The Proportion of Mitochondrial Isoenzyme of Aspartate Aminotransferase Is Not Elevated in Reye's Syndrome

Summary: We reexamined a previously reported, highly specific increase in the relative proportion of the mitochondrial isoenzyme of asparate aminotransferase (AST) in the serum of patients with Reye's Syndrome...

Donald M Mock, Marion Scott, Nell I Mock, M Michael Thaler in Pediatric Research (1983)

Article

607 BIOTIN DEFICIENCY: A NOVEL COMPLICATION OF PARENTERAL ALIMENTATION

All reported cases of biotin deficiency in man have been associated with prolonged ingestion of substantial amounts of raw egg white. A 12-month-old girl developed facial and perineal rash, alopecia totalis, w...

Donald M Mock, William M Liebman, Alfred Delorimier in Pediatric Research (1981)