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  1. Article

    Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities

    Prior conclusions that autologous neonatal red blood cells (RBC) have substantially shorter lifespans than allogeneic adult RBCs were not based on direct comparison of autologous neonatal vs. allogeneic adult ...

    Denison J. Kuruvilla, John A Widness, Demet Nalbant, Robert L Schmidt in Pediatric Research (2017)

  2. Article

    A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis

    Postnatal hemoglobin (Hb) production in anemic preterm infants is determined by several factors including the endogenous erythropoietin levels, allogeneic RBC transfusions administered to treat anemia, and dev...

    Denison J. Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt in The AAPS Journal (2016)

  3. Article

    A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

    Fetal RBCs are produced during a period of very rapid growth and stimulated erythropoiesis under hypoxic intrauterine conditions. Fetal RBC life span varies with gestational age (GA) and is shorter than that i...

    Denison J. Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt in The AAPS Journal (2015)