Abstract
All reported cases of biotin deficiency in man have been associated with prolonged ingestion of substantial amounts of raw egg white. A 12-month-old girl developed facial and perineal rash, alopecia totalis, waxy pallor, hypotonia, and irritability while receiving total parenteral alimentation (TPA) for short gut syndrome. Deficiencies of zinc and essential fatty acids (EFA) were ruled out. Biotin deficiency was documented by biotin levels and urinary excretion of organic acid.
The clinical and biochemical abnormalities resolved with biotin supplementation alone and did not recur with supplementation at normal biotin requirements (0.1 mg/day). Acquired deficiency of biotin, as well as zinc and EFA, must now be considered when rash and alopecia appear in patients receiving TPA.
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Mock, D., Liebman, W. & Delorimier, A. 607 BIOTIN DEFICIENCY: A NOVEL COMPLICATION OF PARENTERAL ALIMENTATION. Pediatr Res 15 (Suppl 4), 541 (1981). https://doi.org/10.1203/00006450-198104001-00620
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DOI: https://doi.org/10.1203/00006450-198104001-00620
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