22 Result(s)

Article

Insights Image for “Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats”

Nynke J. van den Hoogen, J. Patijn, D. Tibboel, E. A. Joosten in Pediatric Research (2020)

Article

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically asses...

E. A. M. Calvier, E. H. J. Krekels, T. N. Johnson, A. Rostami-Hodjegan… in The AAPS Journal (2019)

Article

Population pharmacokinetics of haloperidol in terminally ill adult patients

Over 80% of the terminally ill patients experience delirium in their final days. In the treatment of delirium, haloperidol is the drug of choice. Very little is known about the pharmacokinetics of haloperidol ...

L. G. Franken, R. A. A. Mathot, A. D. Masman… in European Journal of Clinical Pharmacology (2017)

Article

Analgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities

Analgosedation is a fundamental part of traumatic brain injury (TBI) treatment guidelines, encompassing both first and second tier supportive strategies. Worldwide analgosedation practices continue to be heter...

N. Ketharanathan, Y. Yamamoto, U. Rohlwink, E. D. Wildschut… in Child's Nervous System (2017)

Article

Changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation

Thyroid hormone concentrations can be disturbed during critical illness. Our aim was to determine changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation (ECMO).

L Leeuwen, A F J van Heijst, J van Rosmalen, Y B de Rijke… in Journal of Perinatology (2017)

Article

The vulnerable microcirculation in the critically ill pediatric patient

In neonates, cardiovascular system development does not stop after the transition from intra-uterine to extra-uterine life and is not limited to the macrocirculation. The microcirculation (MC), which is essent...

J. W. Kuiper, D. Tibboel, C. Ince in Critical Care (2016)

Article

Cutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging

Incident dark field imaging (IDF) is a new generation handheld microscope for bedside visualization and quantification of microcirculatory alterations. IDF is the technical successor of sidestream dark field i...

H. A. van Elteren, C. Ince, D. Tibboel… in Journal of Clinical Monitoring and Computi… (2015)

Article

Lumbar spine and total-body dual-energy X-ray absorptiometry in children with severe neurological impairment and intellectual disability: a pilot study of artefacts and disrupting factors

Children with severe neurological impairment and intellectual disability (ID) are susceptible for develo** low bone mineral density (BMD) and fractures. BMD is generally measured with dual-energy X-ray absor...

S. Mergler, R. Rieken, D. Tibboel, H. M. Evenhuis, R. R. van Rijn… in Pediatric Radiology (2012)

Article

Determinants of drug absorption in different ECMO circuits

The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits.

E. D. Wildschut, M. J. Ahsman, K. Allegaert, R. A. A. Mathot… in Intensive Care Medicine (2010)

Article

144 Incidence, Risk Factors and Severity of Pulmonary Morbidity in Infants with Congenital Diaphragmatic Hernia Born in High-Volume Centres in Europe

Background and aims: Newborns with congenital diaphragmatic hernia (CDH) may develop chronic lung disease (CLD). Our aim was to determine the incidence, severity and risk factors of CLD in infants with CDH.

L Van Den Hout, I Reiss, T Schaible, I Capolopu, A Van Heijst… in Pediatric Research (2010)

Article

Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation

In most extracorporeal membrane oxygenation (ECMO) centers patients are heavily sedated to prevent accidental decannulation and bleeding complications. In ventilated adults not on ECMO, daily sedation interrup...

E. D. Wildschut, M. N. Hanekamp, N. J. Vet, R. J. Houmes… in Intensive Care Medicine (2010)

Article

Can we improve outcome of congenital diaphragmatic hernia?

This review gives an overview of the disease spectrum of congenital diaphragmatic hernia (CDH). Etiological factors, prenatal predictors of survival, new treatment strategies and long-term morbidity are descri...

L. van den Hout, I. Sluiter, S. Gischler, A. De Klein… in Pediatric Surgery International (2009)

Article

Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age

K Allegaert, M Peeters, R Verbesselt, D Tibboel, G Naulaers, J De Hoon… in Critical Care (2008)

Article

The Critically Ill Adults scale

J Schoonderbeek, P van Leeuwen, B van der Hoven, D Tibboel, M van Dijk in Critical Care (2005)

Article

7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates

Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...

K Allegaert, D Tibboel, H Devlieger, J de Hoon, R Verbesselt… in Pediatric Research (2004)

Article

276 Neonates With Severe Respiratory Insufficiency Requiring ECMO Have Decreased Surfactant Synthesis

Background: Respiratory insufficiency in neonates with congenital diaphragmatic hernia (CDH), meconium aspiration syndrome (MAS) or other forms of persistent pulmonary hypertensin of the newborn (PPHN) is frequen...

L J I Zimmermann, D J Janssen, P E Cogo, A Hamvas, J E Bunt… in Pediatric Research (2004)

Article

6 Impact of Administration of Analgesics During Neonatal Stay on Pain Expression Following Neonatal Stay in Former Preterm Infants

Introduction: There are still few data on the impact of pharmacologic treatment of pain during neonatal stay in preterm infants on pain expression after neonatal stay. We therefore investigated pain expression in...

K Allegaert, A Debeer, G Naulaers, H Devlieger, D Tibboel in Pediatric Research (2004)

Article

Acetaminophen in cerebrospinal fluid in children

There are few studies describing acetaminophen (APAP) cerebrospinal fluid (CSF) concentrations in children. This current study was undertaken in children—from neonates to adolescents—in order to investigate ag...

C. D. van der Marel, B. J. Anderson… in European Journal of Clinical Pharmacology (2003)

Article

Tracheal Ligation and Corticosteroids in Congenital Diaphragmatic Hernia: For Better for Worse?

M Van Tuyl, M Hösgor, D Tibboel in Pediatric Research (2001)

Article

Staff attitudes towards continuation of life-support in newborns with major congenital anomalies

This study was conducted to gain insight into the attitudes of medical staff towards life-support of newborns with life-threatening problems, seen against the background of these children's expected morbidity ...

F. W. J. Hazebroek, R. M. M. Smeets, A. P. Bos, C. Ouwens… in European Journal of Pediatrics (1996)